Relative inotropic and chronotropic activity of beta-adrenoceptor stimulants in anaesthetised, areflexic dogs

European Journal of Pharmacology
B EngelA H Goodman

Abstract

The use of different methods of measuring contractility and the effects of cardiovascular reflexes are among the factors which complicate the assessment of selective inotropic activity of beta-adrenoceptor agonists. The effects of dobutamine, prenalterol, noradrenaline and isoprenaline on heart rate, iliac blood flow, left ventricular pressure, max dP/dt and (dP/dt) divided by IIT (integrated isometric tension) were evaluated in anaesthetised dogs in which the hearts were denervated and blood pressure held constant. All the drugs caused dose-dependent increases in heart rate and contractility. The relative chronotropic and inotropic activity of each agonist was evaluated. At most doses studied the agonists exerted similar chronotropic and inotropic activity when compared to the non-selective agonist isoprenaline. It is likely that the inotropic selectivity observed with prenalterol and dobutamine in previous studies depends on factors other than direct drug action.

References

Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E CarlssonB Tångstrand
Jan 4, 1979·The New England Journal of Medicine·E H SonnenblickT H LeJemtel
Mar 1, 1977·Clinical and Experimental Pharmacology & Physiology·J A AngusA H Goodman
Mar 1, 1977·Clinical and Experimental Pharmacology & Physiology·R Einstein, A M Barrett
Dec 1, 1975·The American Journal of Cardiology·J E Hinds, E W Hawthorne
Jul 1, 1972·Medical & Biological Engineering·A H GoodmanL B Cobbin
May 1, 1974·Circulation Research·N W RobieJ L McNay
Jan 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·N RohmH J Schümann

Citations

Oct 8, 1985·European Journal of Pharmacology·B EngelA H Goodman

Related Concepts

Adrenergic beta-Agonists
Metazoa
Oxiken
Canis familiaris
Pulse Rate
Myocardial Contraction
Norepinephrine, (+, -)-Isomer
Dalzic
Prenalterol Hydrochloride

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