Relative Leukocyte Telomere Length, Hematological Parameters and Anemia - Data from the Berlin Aging Study II (BASE-II)

Gerontology
Antje MeyerIlja Demuth

Abstract

The length of the chromosome ends, telomeres, is widely accepted as a biomarker of aging. However, the dynamic of the relationship between telomere length and hematopoietic parameters in the normal aging process, which is of particular interest with respect to age-related anemia, is not well understood. We have analyzed the relationship between relative leukocyte telomere length (rLTL) and several hematological parameters in the older group of the Berlin Aging Study II (BASE-II) participants. This paper also compares rLTL between both BASE-II age groups (22-37 and 60-83 years). Genomic DNA was extracted from peripheral blood leukocytes of BASE-II participants and used to determine rLTL by a quantitative PCR protocol. Standard methods were used to determine blood parameters, and the WHO criteria were used to identify anemic participants. Telomere length data were available for 444 younger participants (28.4 ± 3.1 years old; 52% women) and 1,460 older participants (68.2 ± 3.7 years old; 49.4% women). rLTL was significantly shorter in BASE-II participants of the older group (p = 3.7 × 10-12) and in women (p = 4.2 × 10-31). rLTL of older men exhibited a statistically significant, positive partial correlation with mean corpuscular h...Continue Reading

Citations

Aug 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Valentin Max VetterIlja Demuth
Dec 12, 2018·The American Journal of Clinical Nutrition·Marij GielenUNKNOWN TELOMAAS group
Jun 27, 2019·International Journal of Molecular Sciences·Verena L BanszerusIlja Demuth
Apr 24, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Valentin Max VetterIlja Demuth
Jun 4, 2020·Aging and Disease·Eva PohlSandra Laurentino

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