Relative localizing value of amygdalo-hippocampal MR biometry in temporal lobe epilepsy

Epilepsy Research
Pedro M Gonçalves PereiraPedro Rosado

Abstract

The aims of the study were (i) to examine the localizing value of three MRI quantitative modalities (qMRI) currently used for the analysis of the hippocampus and amygdala in the context of pre-surgical screening and (ii) to propose a step-by-step protocol based on the sensitivity and performance of the different MR techniques. Ninety-two adults with chronic mesial temporal lobe epilepsy (TLE) of which 28 underwent amygdalo-hippocampal resection, and 34 age-matched controls were included in the study. High-resolution qMRI was performed at 1.5 T, including a tilted T1-weighted 3D-dataset for volumetry and four-echoes T2 relaxometry (both for hippocampus and amygdala quantifications) and multi-voxel spectroscopy [NAA/(Cho+Cre)] (exclusively in the hippocampus). Individual qMRI data were compared with electroencephalography regarding the localization of the epileptogenic area, with the neuropathological data and with postoperative outcome. MRI pathology was defined based on 99% confidence ellipses. Ten controls were used to assess the quantitative MRI intra- and inter-observer variability for all variables. Volumetric measurements revealed unilateral damage in 77% of the patients, T2-relaxometry in 64% and spectroscopy in 53%. Addi...Continue Reading

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Citations

Sep 4, 2010·Annals of Indian Academy of Neurology·Prasad VannemreddyKonstantin V Slavin
Dec 19, 2015·Human Brain Mapping·Maged GoubranAli R Khan
Feb 10, 2011·Neuroscience Letters·Asht Mangal MishraHal Blumenfeld
Apr 10, 2014·Frontiers in Neurology·Francesca PittauSerge Vulliemoz
Dec 16, 2016·Disease Markers·Karabekir ErcanHalil Arslan
Aug 2, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kourosh Jafari-KhouzaniHamid Soltanian-Zadeh

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