Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat

Anesthesia and Analgesia
S Sarraf-YazdiD S Warner

Abstract

Both dizocilpine (MK-801) and isoflurane antagonize glutamatergic neurotransmission. In this study, we examined the relative neuroprotective effects of these drugs administered in equianesthetic doses before the onset of focal cerebral ischemia. Rats were anesthetized with 1.0%-1.5% isoflurane and surgically prepared for filament occlusion of the middle cerebral artery (MCAO). After preparation, one group (n = 22) remained anesthetized with 0.7% isoflurane. Another group (n = 18) was given dizocilpine (1 mg/kg intraperitoneally), and isoflurane was discontinued. The third group (n = 18) was allowed to awaken immediately after the onset of ischemia. MCAO persisted for 75 min. Epidural temperature was controlled at 37.5 degrees C during ischemia and the first 22 h of recovery. A 7-day recovery interval was allowed. Total infarction volumes (mean +/- SD) were less for the dizocilpine group (100 +/- 65 mm3) versus the awake group (182 +/- 36 mm3; P = 0.001). Infarction volumes did not differ significantly between the isoflurane group (142 +/- 81 mm3) and either the dizocilpine (P = 0.11) or the awake group (P = 0.15). Isoflurane was examined at doses used clinically but smaller than those found to reduce N-methyl-D-aspartate (NMDA)...Continue Reading

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Citations

Oct 23, 2012·Chinese Journal of Integrative Medicine·Qing CaiChun-Shen Li
Dec 26, 2001·Anesthesiology·Breandan L SullivanPhilip E Bickler
Apr 27, 2005·Anesthesiology·Michael SchmidtUwe Schirmer
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Apr 25, 2012·Journal of Cell Science·Mei ZhengQi Wan
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Sep 29, 2009·Journal of Neurochemistry·Yuexin ShanQi Wan
May 17, 2008·CNS Neuroscience & Therapeutics·Yoshinori KotaniHideaki Hara

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