Relative peak exercise oxygen pulse is related to sudden cardiac death, cardiovascular and all-cause mortality in middle-aged men

European Journal of Preventive Cardiology
Jari A LaukkanenSetor K Kunutsor

Abstract

Background Preliminary evidence suggests that peak exercise oxygen pulse - peak oxygen uptake/heart rate-, a variable obtained during maximal cardiopulmonary exercise testing and a surrogate of stroke volume, is a predictor of mortality. We aimed to assess the associations of peak exercise oxygen pulse with sudden cardiac death, fatal coronary heart disease and cardiovascular disease and all-cause mortality. Design A prospective study. Methods Peak exercise oxygen pulse was assessed in a maximal cycling test at baseline in 2227 middle-aged men of the Kuopio Ischaemic Heart Disease cohort study using expired gas variables and electrocardiograms. Relative peak exercise oxygen pulse was obtained by dividing the absolute value by body weight. Results During a median follow-up of 26.1 years 1097 subjects died; there were 220 sudden cardiac deaths, 336 fatal coronary heart diseases and 505 fatal cardiovascular diseases. Relative peak exercise oxygen pulse (mean 19.5 (4.1) mL per beat/kg/102) was approximately linearly associated with each outcome. Comparing extreme quartiles of relative peak exercise oxygen pulse, hazard ratios (95% confidence intervals) for sudden cardiac death, fatal coronary heart disease and cardiovascular diseas...Continue Reading

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Citations

Feb 14, 2019·European Journal of Preventive Cardiology·Cosimo CarrierePiergiuseppe Agostoni
Jun 13, 2019·European Journal of Preventive Cardiology·Massimo F Piepoli
Oct 24, 2019·European Journal of Preventive Cardiology·Claudio Gil S Araújo, Jari A Laukkanen
Mar 21, 2019·European Journal of Preventive Cardiology·Frédéric ChaguéMarianne Zeller
Oct 5, 2019·European Journal of Preventive Cardiology·Piergiuseppe AgostoniGaia Cattadori
Dec 4, 2019·European Journal of Preventive Cardiology·Alessandro ZorziPatrizio Sarto
Apr 2, 2020·European Journal of Preventive Cardiology·Erik FungJean Woo
Aug 20, 2019·European Journal of Preventive Cardiology·Jari A LaukkanenSetor K Kunutsor
Oct 24, 2019·European Journal of Preventive Cardiology·James E PetermanLeonard A Kaminsky
Jan 8, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Massimo F PiepoliGiuseppe Rosano
Dec 19, 2019·European Journal of Preventive Cardiology·E CavarrettaM Peruzzi
Mar 3, 2018·European Journal of Preventive Cardiology·Luc Vanhees
Apr 28, 2018·European Journal of Preventive Cardiology·Massimo F Piepoli
Feb 22, 2021·European Journal of Preventive Cardiology·Erik FungJean Woo
Apr 11, 2021·European Journal of Preventive Cardiology·James E PetermanLeonard A Kaminsky

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