Relative performance of brivaracetam as adjunctive treatment of focal seizures in adults: a network meta-analysis

Current Medical Research and Opinion
Mata CharokopouSimon Borghs

Abstract

To estimate the relative efficacy, safety and tolerability of adjunctive brivaracetam and other antiepileptic drugs (AEDs) using a Bayesian network meta-analysis (NMA) approach. A systematic literature review (SLR) identified randomized controlled trials of AEDs treating focal (partial-onset) seizures for ≥8 weeks and assessed them for inclusion in the NMA. Bayesian random-effects NMA was performed for several outcomes. All interventions within the licensed dose range were included in the network of evidence. The SLR identified 82 studies; 65 were included in the NMA. These studies had baseline mean age 33.1-38.0 years, mean duration of epilepsy 18.7-23.0 years and median seizure frequency/28 days 8.1-11.8. All AEDs had significantly higher odds than placebo of achieving ≥50% responder rates (odds ratios 1.83-3.58) and all AEDs had a trend of higher odds than placebo of achieving seizure freedom (odds ratios 1.36-5.73), most being statistically significant. Tolerability outcomes were comparable between AEDs; most AEDs had higher odds than placebo of treatment-emergent adverse events leading to discontinuation, serious AEs, nausea, fatigue, dizziness and somnolence. This NMA would appear to show relative equivalence in efficacy,...Continue Reading

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Citations

Dec 7, 2019·Advances in Therapy·Saku VäätäinenReetta Kälviäinen
Oct 20, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Isabel Barrachina-MartinezFrancisco Reyes-Santias

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