Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice.

Antimicrobial Agents and Chemotherapy
J DescampsD Shugar

Abstract

Thirteen established anti-herpes compounds have been directly compared in a single assay system for their effects on the development of herpetic skin lesions, and mortality associated therewith, in athymic nude (nu/nu) mice inoculated intracutaneously with herpes simplex virus type 1 (KOS). When applied topically (at 1% in a water-soluble ointment), phosphonoacetic acid, E-5-(2-bromovinyl)-2'-deoxyuridine, acycloguanosine, and trisodium phosphonoformate emerged as the most active agents.

References

Sep 1, 1978·Science·E HelgstrandB Oberg
Sep 1, 1978·Antimicrobial Agents and Chemotherapy·S AleniusB Oberg
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E De ClercqR T Walker
Mar 1, 1978·Antimicrobial Agents and Chemotherapy·E De ClercqD Shugar

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Citations

Jan 1, 1982·Pharmacology & Therapeutics·M L LandryG D Hsiung
Jan 1, 1982·Pharmacology & Therapeutics·B Oberg
Jan 1, 1984·Pharmacology & Therapeutics·E De Clercq, R T Walker
Jan 1, 1989·Pharmacology & Therapeutics·B Oberg
Jan 1, 1980·Antimicrobial Agents and Chemotherapy·P C MaudgalA S Jones
Feb 1, 1986·Antimicrobial Agents and Chemotherapy·J SamuelL I Wiebe
Jul 20, 1982·The American Journal of Medicine·E R Kern
Jul 20, 1982·The American Journal of Medicine·M L LandryD R Mayo
Jul 20, 1982·The American Journal of Medicine·E R KernP de Miranda
Dec 1, 1994·Acta Paediatrica Japonica; Overseas Edition·N TabataY Komada
Apr 1, 1984·Clinics in Dermatology·J S Epstein, G V Quinnan

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