Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS

Toxicology and Applied Pharmacology
R J SmialowiczL S Birnbaum

Abstract

The toxic equivalency factor (TEF) approach was employed to compare immunotoxic potency of mixtures containing polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), using the antibody response to sheep erythrocytes (SRBC). Mixture-1 (MIX-1) contained TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 2,3,7,8-tetrachlorodibenzofuran (TCDF), 1,2,3,7,8-pentachlorodibenzofuran (1-PeCDF), 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF), and 1,2,3,4,6,7,8,9-octachlorodibenzofuran (OCDF). Mixture-2 (MIX-2) contained MIX-1 and the following PCBs, 3,3',4,4'-tetrachlorobiphenyl (IUPAC No. 77), 3,3',4,4',5-pentachlorobiphenyl (126), 3,3',4,4',5,5N-hexachlorobiphenyl (169), 2,3,3',4,4'-pentachlorobiphenyl (105), 2,3',4,4',5-pentachlorobiphenyl (118), and 2,3,3',4,4',5-hexachlorobiphenyl (156). The mixture compositions were based on relative chemical concentrations in food and human tissues. TCDD equivalents (TEQ) of the mixture were estimated using relative potency factors from hepatic enzyme induction in mice [DeVito, M.J., Diliberto, J.J., Ross, D.G., Menache, M.G., Birnbaum, L.S., 1997. Dose-response relationships for polyhalogenated dioxins a...Continue Reading

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May 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·J J DilibertoL S Birnbaum
Jan 29, 2002·International Immunopharmacology·Nancy I Kerkvliet
Dec 3, 2002·Human & Experimental Toxicology·R J Smialowicz
Jul 11, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Martin Van den BergRichard E Peterson

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Citations

Jul 8, 2010·Chemosphere·Jesús Olivero-VerbelCarlos Ortega-Zúñiga
Oct 31, 2015·Environmental Science and Pollution Research International·Seyedeh Belin Tavakoly SanyEbrahim Abouzari-Lotf
May 9, 2015·Environmental Science and Pollution Research International·Seyedeh Belin Tavakoly SanyDavid J Karlen
Feb 18, 2011·Environmental Research·Chihiro MiyashitaReiko Kishi
Nov 23, 2017·Environmental Health and Preventive Medicine·Reiko KishiUNKNOWN members of The Hokkaido Study on Environment and Children’s Health

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