PMID: 1201380Oct 1, 1975Paper

Relative potency of bombesin-like peptides

British Journal of Pharmacology
M BroccardoR de Castiglione

Abstract

The pharmacological activity of two natural bombesin-like peptides, alytesin and litorin, and 25 related synthetic peptides has been compared to that of bombesin. 2 The minimum length of the amino acid chain required for the first appearance of bombesin-like effects was represented by the C-terminal heptapeptide, and the minimum length for maximal effects by the C-terminal nonapeptide. The latter possessed approximately the same activity as bombesin and may be considered a good substitute. 3 Both the tryptophan and histidine residues seemed to be essential for bombesin-like activity. 4 The C-terminal octapeptide was less active than either bombesin or the C-terminal nonapeptide and its action was more rapid in onset and less sustained. 5 Litorin apparently has an intermediate position between bombesin octapeptide and bombesin nonapeptide in the speed and duration of its effects. The relationship between structure and activity is discussed.

Citations

Sep 6, 2002·Journal of Peptide Science : an Official Publication of the European Peptide Society·Dirk WeberHorst Kessler
Dec 1, 1991·Trends in Neurosciences·J Battey, E Wada
Jan 1, 1986·Regulatory Peptides·S LemaireR Day
Jun 1, 1988·Regulatory Peptides·R MichelettiG M Makhlouf
Sep 10, 1990·Regulatory Peptides·M Thorndyke, S Holmgren
Sep 1, 1984·Peptides·M S OrloffJ H Walsh
Jan 1, 1983·Neuroscience·M Schultzberg
Jan 11, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M C ThorndykeS R Vigna
Oct 1, 1996·Critical Reviews in Oncology/hematology·R de Castiglione, L Gozzini
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T W MoodyM R Brown
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E Rozengurt, J Sinnett-Smith
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G GaudinoP M Comoglio
Feb 14, 1990·European Journal of Biochemistry·J A Carver, J G Collins
May 1, 1991·British Journal of Pharmacology·N RouissiD Regoli
Jun 23, 2009·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Amanda L MartinElizabeth R Gillies
Aug 27, 2015·Journal of Medicinal Chemistry·Ibai E ValverdeThomas L Mindt

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