Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay

Environmental Health Perspectives
S R MilliganJ C Kalita

Abstract

The in vivo effects of xenoestrogens are of interest in relation to their potential health risks and/or beneficial effects on humans and animals. However, the apparent in vivo potency of the examined response can be confounded by a short half-life, and the metabolism of estrogens is very dependent on the nature of conversion and/or inactivation. To minimize such variables, we examined the estrogenic potency of a range of xenoestrogens in an acute in vivo assay--the stimulation of increased uterine vascular permeability in ovariectomized mice 4 hr after subcutaneous administration. While estradiol (E 2 ) and estriol (E 3 ; a relatively weak natural estrogen) readily induced vascular responses [median effective dose (ED 50 ) <10 -9 mol], much higher amounts of xenoestrogens were required. Bisphenol A was about 10,000-fold less potent than E 2 and E 3 , and octylphenol and nonylphenol were about 100,000-fold less potent; dioctyl phthalate, benzyl butyl phthalate, dibutyl phthalate, and trichlorinated biphenol produced no effect. Coumestrol was the most active phytoestrogen, with an ED 50 between 10 -6 and 10 -7 mol; genistein was about 10-fold less potent than coumestrol, and neither daidzein nor formononetin produced any marked e...Continue Reading

References

Jul 1, 1977·Acta Physiologica Scandinavica·N G Arvidson
Jan 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G RudaliB Muel
Apr 1, 1976·The Journal of Endocrinology·L MartinB Fagg
Jan 1, 1987·Journal of Reproduction and Fertility·S R Milligan
Sep 1, 1993·Journal of Reproduction and Fertility·P E Cohen, S R Milligan
May 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·L MarkiewiczE Gurpide

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Citations

Mar 4, 2008·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·A R FernandesC Charlton
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MäkeläP Häyry
Nov 9, 2004·Environmental Health Perspectives·Josephine G LemmenBart van der Burg
Nov 7, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H NakazawaT Makino
Jan 10, 2002·Reproductive Toxicology·M EmaA Harazono
May 18, 2005·Food Additives and Contaminants·B M Thomson, P R Grounds
Aug 31, 1999·The Proceedings of the Nutrition Society·I Rowland
Dec 4, 2003·Biochemical and Biophysical Research Communications·Tomohiro OkaKouichi Kurose
Mar 26, 2004·Ecotoxicology and Environmental Safety·S PawlowskiT Braunbeck
Jan 12, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Calvin C WillhiteClifton J McLellan
Apr 27, 2001·Toxicology Letters·B Heinrich-HirschU Gundert-Remy
Mar 23, 2002·Climacteric : the Journal of the International Menopause Society·A Cassidy, S Milligan
Jan 5, 2002·Environmental Toxicology and Chemistry·C BergB Brunström
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Shuk-Mei HoYuet-Kin Leung
May 27, 2004·Journal of Biomedical Materials Research. Part a·Homa Darmani, Ahmad S Al-Hiyasat
Jun 6, 2003·Environmental Toxicology and Chemistry·James GartshoreJim A Nicell
Jun 24, 2004·Risk Analysis : an Official Publication of the Society for Risk Analysis·Justin G Teeguarden, Hugh A Barton
Oct 18, 2005·Molecular and Cellular Endocrinology·Alzbeta MlynarcíkováSona Scsuková
Nov 20, 2016·Nature Reviews. Endocrinology·Joseph M Braun
Dec 6, 2005·Journal of Toxicology and Environmental Health. Part a·Hyung Sik KimSoon-Young Han
Jul 23, 2002·Journal of Toxicology and Environmental Health. Part a·Petri S Koponen, Jussi V K Kukkonen
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Duck Soo LimByung Mu Lee
Jun 29, 2017·Environmental Health Perspectives·Joseph M BraunBruce P Lanphear
Jun 22, 2000·Toxicologic Pathology·R Nilsson
Jun 29, 2005·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
May 25, 2004·European Journal of Oral Sciences·Ahmad S Al-HiyasatAhmed M Elbetieha
Nov 12, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Mohammad Shah AlamMasamichi Kurohmaru
Dec 23, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Karl K RozmanDavid Umbach

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