Relative precision of inhaler aerodynamic particle size distribution (APSD) metrics by full resolution and abbreviated andersen cascade impactors (ACIs): part 2--investigation of bias in extra-fine mass fraction with AIM-HRT impactor.

AAPS PharmSciTech
Jolyon MitchellSvetlana Lyapustina

Abstract

The purpose of this study was to resolve an anomalously high measure of extra-fine particle fraction (EPF) determined by the abbreviated cascade impactor possibly relevant for human respiratory tract (AIM-HRT) in the experiment described in Part 1 of this two-part series, in which the relative precision of abbreviated impactors was evaluated in comparison with a full resolution Andersen eight-stage cascade impactor (ACI). Evidence that the surface coating used to mitigate particle bounce was laterally displaced by the flow emerging from the jets of the lower stage was apparent upon microscopic examination of the associated collection plate of the AIM-HRT impactor whose cut point size defines EPF. A filter soaked in surfactant was floated on top of this collection plate, and further measurements were made using the same pressurized metered-dose inhaler-based formulation and following the same procedure as in Part 1. Measures of EPF, fine particle, and coarse particle fractions were comparable with those obtained with the ACI, indicating that the cause of the bias had been identified and removed. When working with abbreviated impactors, this precaution is advised whenever there is evidence that surface coating displacement has oc...Continue Reading

References

Mar 4, 1992·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M Dolovich
Oct 24, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Dave ChristopherUNKNOWN PQRI Particle Size Distribution Mass Balance Working Group
Jan 20, 2004·AAPS PharmSciTech·V V Sethuraman, A J Hickey
Feb 24, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Jolyon P Mitchell, Mark W Nagel
Jul 19, 2005·International Journal of Pharmaceutics·Craig DunbarTiba Tiangbe
Apr 24, 2008·AAPS PharmSciTech·Matthew BonamBruce Wyka

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Citations

Jun 26, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kamrun NaharFakhrul Ahsan
Mar 15, 2012·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Carole EvansPatricia Watson
Feb 28, 2013·Therapeutic Delivery·Gabriela Apiou-SbirleaAnthony Hickey
Feb 3, 2011·AAPS PharmSciTech·Terrence P TougasVolker Glaab

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