Relative predispositional effects and mode of inheritance of HLA-DRB1 alleles among community-based Caucasian females with rheumatoid arthritis

Genetic Epidemiology
H MuL A Criswell

Abstract

Multiple HLA-DRB1 alleles encoding a shared epitope (SE) at amino acid positions 70-74 are associated with susceptibility to rheumatoid arthritis (RA). However, the nature of the association and the mode of inheritance differ depending upon the source of RA patients and laboratory methodology. We studied the relative predispositional effects (RPE) and mode of inheritance of DRB1 alleles among a community-based sample of 180 RA patients and 116 healthy controls, all Caucasian females. Polymerase chain reaction (PCR)-based assays were used for DRB1 genotyping, and the genotypic distributions were analyzed by both the RPE and antigen genotype frequency among patients (AGFAP) methods. We examined the evidence of synergy among DRB1 alleles for RA risk by comparing the observed DRB1 genotype distribution to that predicted under Hardy-Weinberg equilibrium. Fifty-six percent of RA cases were attributable to DRB1 alleles encoding the SE. The RPEs of DRB1 alleles were *0401 > *0404 > *1001 > *0408 > *0101. The strength of the RA association was not significantly different for these alleles. The AGFAP analysis was consistent with a recessive mode of inheritance for DRB alleles, while an additive (dominant) model was rejected. We found no ...Continue Reading

References

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Citations

Feb 14, 2002·Rheumatic Diseases Clinics of North America·George Moxley, Harley J Cohen
Oct 18, 2000·Rheumatology·E ZanelliR R de Vries
Sep 5, 2002·Genes and Immunity·A GülG Saruhan-Direskeneli
Oct 21, 2018·Annals of the Rheumatic Diseases·John D ReveilleMatthew A Brown
Oct 4, 2006·International Journal of Cancer. Journal International Du Cancer·Kirsten KüblerKatrin van der Ven

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