PMID: 9176536May 1, 1997Paper

Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome

Thorax
L Armstrong, A Millar

Abstract

The adult respiratory distress syndrome (ARDS) may be regarded as an example of an uncontrolled or excessive inflammatory response in which tumour necrosis factor alpha (TNF-alpha) has been proposed to play a central role. Interleukin 10 (IL-10) has been identified as an important regulator of this response. The potential role for IL-10 in this context was investigated by measuring the relative production of IL-10 and TNF-alpha protein in the plasma, bronchoalveolar lavage (BAL) fluid, and alveolar macrophage culture supernatants of patients with, or at risk of developing, ARDS. Twenty six patients were studied from three groups at risk of or with ARDS: sepsis (n = 12), multiple trauma (n = 8), and perforated bowel (n = 6). Ten patients had ARDS. Bronchoalveolar lavage and venepuncture were performed within 24 hours of arrival on the intensive therapy unit or of diagnosis of ARDS. IL-10 and TNF-alpha protein were detected in the plasma, BAL fluid, and alveolar macrophage supernatants by sandwich enzyme linked immunoabsorbent assays. The median IL-10 concentrations in the plasma and BAL fluid of patients with ARDS were significantly lower than the concentrations detectable in the plasma (median difference-17.5, 95% CI -52.4 to 1...Continue Reading

References

Feb 1, 1992·The Journal of Experimental Medicine·D AderkaD Wallach
Jun 1, 1988·The American Review of Respiratory Disease·K E StephensT A Raffin
Sep 1, 1988·The American Review of Respiratory Disease·J F MurrayM R Flick
Aug 12, 1967·Lancet·D G AshbaughB E Levine
Sep 1, 1983·Chest·W M AlbertsK M Moser
Apr 15, 1982·The New England Journal of Medicine·J E Rinaldo, R M Rogers
Mar 19, 1994·Lancet·A MarchantM Goldman
May 1, 1994·The Journal of Experimental Medicine·P D KatsikisM Feldmann
Apr 1, 1993·The Journal of Experimental Medicine·M HowardS Menon
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·J PuginT R Martin

❮ Previous
Next ❯

Citations

Sep 4, 2004·Indian Journal of Pediatrics·Anil VasudevanS K Kabra
Oct 18, 2003·Cytokine & Growth Factor Reviews·Richard B GoodmanMichael A Matthay
May 23, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Isabelle Noël-GeorisRuddy Wattiez
May 7, 1999·Histopathology·P S Hasleton, T E Roberts
Oct 17, 2001·Surgery·S G MuehlstedtJ L Rodriguez
Oct 2, 2001·Mediators of Inflammation·G V ShmarinaN J Kashirskaja
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Yan ZhangXiaojing Ma
Mar 27, 2007·Surgical Infections·Tercio De CamposRaul Coimbra
Dec 21, 2010·Surgical Infections·Mark A JonkerKenneth A Kudsk
Jan 11, 2000·Critical Care Medicine·M O SimovicJ A Windsor
Sep 3, 2002·Current Opinion in Critical Care·Jesús Villar
Apr 12, 2003·Critical Care Medicine·Jesús VillarSebastián Méndez-Alvarez
Jul 9, 2004·Critical Care Medicine·Lila BouadmaGeorges Saumon
Oct 11, 2005·Critical Care Medicine·Christian HofstetterBernhard Zwissler
Sep 21, 2004·Shock·Rachel G KhadarooOri D Rotstein
Mar 21, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Margaret Kurzius-SpencerJefferey L Burgess
Feb 23, 2010·The Journal of Trauma·Mark A JonkerKenneth A Kudsk
Apr 7, 2010·Science Translational Medicine·Marcelo CypelShaf Keshavjee
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·W Y ParkT R Martin
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·D R ThickettA B Millar
Apr 6, 2006·The European Respiratory Journal·M N GongD C Christiani
Aug 22, 2003·Critical Care : the Official Journal of the Critical Care Forum·Grant W Waterer, Richard G Wunderink
Sep 19, 2009·Pharmacogenomics·Anita J Reddy, Steven R Kleeberger
Oct 3, 2006·Current Opinion in Anaesthesiology·W T McBride, S J McBride
Mar 17, 2016·Disease Markers·Raiko BlondonnetMatthieu Jabaudon
Jan 26, 2010·The Journal of Surgical Research·Akira HasegawaTakayuki Noguchi
Sep 5, 2009·Injury·Takeshi TsukamotoHans-Christoph Pape
Dec 1, 2007·Injury·Andreas LenzWilliam G Cheadle
Jun 26, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Li GaoJoe G N Garcia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.