Relative Prognostic Importance and Optimal Levels of Risk Factors for Mortality and Cardiovascular Outcomes in Type 1 Diabetes Mellitus

Circulation
Aidin RawshaniSoffia Gudbjörnsdottir

Abstract

The strength of association and optimal levels for risk factors related to excess risk of death and cardiovascular outcomes in type 1 diabetes mellitus have been sparsely studied. In a national observational cohort study from the Swedish National Diabetes Register from 1998 to 2014, we assessed relative prognostic importance of 17 risk factors for death and cardiovascular outcomes in individuals with type 1 diabetes mellitus. We used Cox regression and machine learning analyses. In addition, we examined optimal cut point levels for glycohemoglobin, systolic blood pressure, and low-density lipoprotein cholesterol. Patients with type 1 diabetes mellitus were followed up until death or study end on December 31, 2013. The primary outcomes were death resulting from all causes, fatal/nonfatal acute myocardial infarction, fatal/nonfatal stroke, and hospitalization for heart failure. Of 32 611 patients with type 1 diabetes mellitus, 1809 (5.5%) died during follow-up over 10.4 years. The strongest predictors for death and cardiovascular outcomes were glycohemoglobin, albuminuria, duration of diabetes mellitus, systolic blood pressure, and low-density lipoprotein cholesterol. Glycohemoglobin displayed ≈2% higher risk for each 1-mmol/mol ...Continue Reading

References

May 26, 2001·Diabetes Care·T J OrchardUNKNOWN Pittsburgh Epidemiology of Diabetes Complications Study
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Apr 1, 2008·Diabetes Care·Sabita S Soedamah-MuthuUNKNOWN EURODIAB Prospective Complications Study Group
Sep 24, 2008·Archives of Internal Medicine·Ian H de BoerUNKNOWN Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Resear
Apr 30, 2009·Diabetes·Per-Henrik GroopUNKNOWN FinnDiane Study Group
May 24, 2011·Journal of Diabetes and Its Complications·Juan J ChillarónJuan Pedro-Botet
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Dec 23, 2011·Biostatistics·Glenn Heller
Nov 20, 2014·The New England Journal of Medicine·Marcus LindAnnika Rosengren
Jan 1, 2015·Diabetes Research and Clinical Practice·Björn Eliasson, Soffia Gudbjörnsdottir
Jan 7, 2015·JAMA : the Journal of the American Medical Association·Shona J LivingstoneUNKNOWN Scottish Renal Registry
Apr 14, 2017·The New England Journal of Medicine·Aidin RawshaniSoffia Gudbjörnsdottir
Jun 22, 2018·JAMA Cardiology·Stephen BurgessUNKNOWN European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium

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Citations

Apr 3, 2020·Diabetes/metabolism Research and Reviews·C ViñalsA J Amor
Jun 10, 2020·Diabetes/metabolism Research and Reviews·Antonio J AmorVerónica Perea
Jul 11, 2019·Cardiovascular Diabetology·Stefanie Hägg-HolmbergUNKNOWN FinnDiane Study Group
Jun 11, 2020·Current Opinion in Pediatrics·Elżbieta Niechciał, M Loredana Marcovecchio
Nov 27, 2019·European Journal of Preventive Cardiology·Bianca RoccaFrancesco Zaccardi
Aug 11, 2020·Cardiovascular Diabetology·Antonio J AmorDidac Mauricio
Jul 4, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Shoshana TellRobert H Eckel
Oct 22, 2020·Nature Reviews. Endocrinology·Klara R Klein, John B Buse
May 1, 2021·Journal of Clinical Medicine·Cristina ColomAntonio Pérez
Apr 20, 2021·Journal of Diabetes and Its Complications·Chris J KapeliosStavros Liatis
May 25, 2021·Frontiers in Cardiovascular Medicine·Zhiwei LiJing Wang
Jun 3, 2021·Computer Methods and Programs in Biomedicine·Aizatul Shafiqah Mohd FaizalSiow-Wee Chang
Jun 10, 2021·Diabetologia·Stuart J McGurnaghanUNKNOWN Swedish National Diabetes Register and the Scottish Diabetes Research Network Epidemiology Group
Jun 29, 2021·Frontiers in Pediatrics·Scott T Chiesa, M Loredana Marcovecchio
Aug 7, 2021·Biomedicines·Stephen T O'BrienTimothy O'Brien
Aug 31, 2021·European Heart Journal·Frank L J VisserenUNKNOWN ESC Scientific Document Group
Aug 31, 2021·Frontiers in Endocrinology·Anqi ChenYanan Li
Sep 18, 2021·Frontiers in Physiology·Junfa XueLixin Xie
Sep 4, 2020·Current Drug Safety·Anna Pietraszek
Sep 25, 2021·European Journal of Preventive Cardiology·Frank L J VisserenUNKNOWN ESC Scientific Document Group
Sep 18, 2021·The Canadian Journal of Cardiology·Jeremy PetchWalter Nelson

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