Relative Prognostic Value of Cardiac Troponin I and C-Reactive Protein in the General Population (from the Nord-Trøndelag Health [HUNT] Study)

The American Journal of Cardiology
Fjola D SigurdardottirTorbjørn Omland

Abstract

C-reactive protein and cardiac troponin I measured with high-sensitivity assays (high-sensitivity C-reactive protein [hs-CRP] and high-sensitivity troponin I [hs-TnI]) have been associated with risk of fatal and nonfatal cardiovascular events in the general population. The relative prognostic merits of hs-CRP and hs-TnI, and whether these markers of inflammation and subclinical myocardial injury provide incremental information to established cardiovascular risk prediction models, remain unclear. hs-CRP and hs-TnI were measured in 9,005 participants from the prospective observational Nord-Trøndelag Health (HUNT) study. All study subjects were free from known cardiovascular disease at baseline. During a median follow-up period of 13.9 years, 733 participants reached the composite end point of hospitalization for acute myocardial infarction or heart failure, or cardiovascular death. In adjusted models, increased hs-TnI concentrations (>10 ng/L for women and >12 ng/L for men) were associated with the incidence of the composite end point (hazard ratio 3.61, 95% confidence interval [CI] 2.89 to 4.51]), whereas the risk associated with increased hs-CRP concentrations (>3 mg/L for both genders) appeared to be weaker (HR 1.71, 95% CI 1....Continue Reading

Citations

Apr 4, 2019·Biomarkers in Medicine·Claudio PassinoAldo Clerico
May 23, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoMario Plebani
Jul 22, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoMario Plebani
Apr 2, 2020·Current Cardiology Reports·Michael C Kontos, Jeremy S Turlington
Feb 18, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Qin JiangShengshou Hu
Jul 29, 2020·The Journal of Sports Medicine and Physical Fitness·Marco A PerroneAldo Clerico
Aug 28, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Daniela Maria CardinaleAldo Clerico
Jan 28, 2021·European Heart Journal. Quality of Care & Clinical Outcomes·Paul Jülicher, Christos Varounis
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoMario Plebani
Feb 11, 2021·Journal of Translational Medicine·Chris J WatsonKen McDonald
Feb 26, 2021·Journal of Sleep Research·Fjola D SigurdardottirTorbjørn Omland
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Aug 10, 2021·Vascular Health and Risk Management·Aleksey Chaulin
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Jul 6, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Aldo ClericoMario Plebani
Jan 6, 2021·Journal of Cardiovascular Medicine·Marco A PerroneAldo Clerico

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