Relative protective activities of quercetin, quercetin-3-glucoside, and rutin in alcohol-induced liver injury

Journal of Food Biochemistry
Seyun LeeJeehye Sung

Abstract

Alcoholic liver diseases has been known to be one of the major health risks worldwide. The purpose of this study was aimed to demonstrate the relative protective effect of quercetin, quercetin-3-glucoside, and rutin on alcohol-induced damage in hepatocytes. The hepatotoxicity, antioxidant enzymatic defense mechanisms, and pro-inflammatory mediators were examined for evaluating the hepatoprotective effects of quercetins in hepG2 cells. The results revealed that quercetin and its glucoside derivatives significantly prevented ethanol-induced hepatotoxicity by decreasing hepatic aminotransferase activities and inflammatory response in HepG2 cells. Moreover, the quercetins significantly induced detoxifying enzymes via the nuclear accumulation of the NF-E2-related factor 2 (Nrf2) and induction of antioxidant response element (ARE) gene. These hepatoprotective activities were observed to be more effective with quercetin aglycone than quercetin glucosides. From the above findings, the present study imply that quercetin aglycone may have a vital function in the therapeutic and preventive strategies of alcoholic liver diseases. PRACTICAL APPLICATIONS: Quercetin is commonly present in fruits and vegetables as aglycone and glucoside-derive...Continue Reading

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Citations

Jul 20, 2021·Critical Reviews in Food Science and Nutrition·Liang ZouJianbo Xiao
Jul 16, 2021·Chemical Research in Toxicology·Milon MondalSukalyan Kumar Kundu
Jul 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yajie CaiRunping Liu
Oct 16, 2021·Journal of Food Biochemistry·Xiaoling ChenGuangmang Liu

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