Relative risk of knee chondrocalcinosis in siblings of index cases with pyrophosphate arthropathy

Annals of the Rheumatic Diseases
W ZhangMichael Doherty

Abstract

To examine the genetic contribution to common, apparently sporadic, radiographic knee chondrocalcinosis (CC) and pyrophosphate arthropathy (PA). (1). radiographic sibling study. Comparison of the prevalences of knee CC and PA in siblings of index cases with PA with those in the community. (2). 80 index cases with PA listed for total knee replacement; 122 of their siblings aged >or=40 years; and 1729 participants from community knee pain surveys who had undergone knee radiographs. (3). odds ratios of knee CC and PA in siblings versus community participants. The prevalence of knee CC was 13% (15/116) in the siblings and 6.9% (119/1727) in the community participants. The adjusted odds ratio (aOR) was 1.2, 95% confidence interval (CI) 0.6 to 2.3. The main risk factors for knee CC were age, knee pain, and knee OA. The prevalence of knee PA was 7% (9/122) in the siblings and 3.4% (59/1729) among the community participants (aOR = 1.1, 95% CI 0.4 to 2.7). The main risk factors for PA were age and knee pain. The age, sex, and knee pain standardised prevalence of PA in the Nottingham community aged >or=40 was 2.40%. The risk of knee CC and PA in siblings of index cases with PA is no higher than that in the general population. Although ra...Continue Reading

References

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Citations

Nov 26, 2010·Nature Reviews. Rheumatology·Abhishek Abhishek, Michael Doherty
Aug 14, 2012·Rheumatology·Young Hee RhoHyon K Choi
Apr 20, 2005·Current Opinion in Rheumatology·Yun Zhang, Matthew A Brown
Jul 27, 2012·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Andreas P DiamantopoulosGlenn Haugeberg
May 29, 2007·Current Rheumatology Reports·Ana Rita Couto, Matthew A Brown
Apr 8, 2014·Rheumatic Diseases Clinics of North America·Abhishek Abhishek, Michael Doherty
Jan 15, 2013·Rheumatic Diseases Clinics of North America·A Abhishek, Michael Doherty
Mar 23, 2007·Osteoarthritis and Cartilage·D A WalshD F McWilliams
Nov 25, 2014·Foot & Ankle International·Adam LomaxDishan Singh
Feb 7, 2007·Current Opinion in Rheumatology·Ann K Rosenthal
Dec 1, 2007·Arthritis and Rheumatism·Pascal RichetteThomas Bardin
May 7, 2019·International Journal of Rheumatic Diseases·Yilun WangGuanghua Lei
May 22, 2018·Internal Medicine·Masahiro Yamamura
Dec 19, 2019·Arthritis Research & Therapy·Mohaned HameedMeliha C Kapetanovic

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