Relative sensitivity of Tc-99m WBC versus In-111 WBC in a patient with Crohn's disease on steroids

Clinical Nuclear Medicine
K P LyonsN Milne

Abstract

Numerous studies have shown that chemotaxis is affected by certain antibiotics and steroids. A patient had Crohn's disease in relapse with multiple small bowel fistulae and mesenteric abscesses. Although the Tc-99m WBC scan did not show the intra-abdominal inflammatory foci, an In-111 WBC scan performed within a week delineated the abscesses and these were later confirmed at surgery. This case is being presented not only to show the relative sensitivities of a Tc-99m WBC vs. an In-111 WBC scan, but also to discuss the impediment to polymorphonuclear leukocyte chemotaxis by steroids, which may be a contributory factor to the sensitivities of the different radiopharmaceuticals selected for detection of intra-abdominal septic foci.

References

May 1, 1992·The Journal of Surgical Research·J A FreischlagW S Moore
Jul 1, 1991·Agents and Actions·D A LomasR A Stockley
Jan 1, 1990·Immunopharmacology and Immunotoxicology·J S RossR D Camp
Feb 1, 1996·American Journal of Respiratory and Critical Care Medicine·C G Llewellyn-JonesR A Stockley

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Citations

Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·M A Del RosarioS K Gupta

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