Relative survival analysis of 252 patients with COPD receiving long-term oxygen therapy

Chest
P FoucherL Jeannin

Abstract

A survival analysis was conducted on patients with COPD receiving long-term oxygen therapy (LTOT) to compare two different statistical methods. We used a multivariate crude (observed) survival model (Cox) and a multivariate relative survival model (Hakulinen). Only the latter is able to correct the survival by adjusting it to the normal life expectancy of the studied patients. Two hundred fifty-two hypoxemic COPD patients (207 male) requiring LTOT were included. Mean PaO2 was <50 mm Hg before oxygen therapy. Mean age was >69 years (SE: 9.9). They had severe bronchial obstruction: mean FEV1 was <33% (10.6) of predicted values, with some CO2 retention: mean PaCO2 was 45.6 (7.1) mm Hg. By December 31, 1995, 189 patients had died (75%) and 13 (5%) were unavailable for follow-up. The overall crude survival was poor: 80.9% after 1 year, 67.1% after 2 years, 34.7% after 5 years, and 7.1% after 10 years. In the crude multivariate analysis (Cox), the negative prognostic factors were age and hypercapnia. The overall relative survival (Hakulinen), corrected for life expectancy, was 82.8% after 1 year, 70.8% after 2 years, 41.5% after 5 years, and 10.25% after 10 years. In the final multivariate relative model, age was no longer significan...Continue Reading

References

Jan 1, 1992·Respiration; International Review of Thoracic Diseases·W MacNee
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Christensen
Jan 1, 1985·Computer Programs in Biomedicine·T Hakulinen, K H Abeywickrama
Jan 1, 1985·Respiration; International Review of Thoracic Diseases·R KellerP Borer
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·K MiyamotoY Kawakami
Jan 1, 1994·Respiration; International Review of Thoracic Diseases·R DallariP L Tartoni
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P FoucherL Jeannin

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Citations

Mar 31, 2000·Current Opinion in Pulmonary Medicine·K Nishimura, M Tsukino
Jun 16, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Qiuyue Wang, Jean Bourbeau
Mar 18, 2006·American Journal of Respiratory and Critical Care Medicine·Fernando J MartinezUNKNOWN NETT Research Group
Dec 13, 2005·Treatments in Respiratory Medicine·Thomas J Ringbaek
Aug 15, 2008·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Zorica LazićVojislav Cupurdija
Jan 28, 2014·Archivos de bronconeumología·Francisco Ortega RuizJulia Tàrrega Camarasa
Apr 8, 2014·Respiratory Medicine·Jonathan A GalliGerard J Criner
Jul 28, 2010·QJM : Monthly Journal of the Association of Physicians·J SteerS C Bourke
Oct 1, 2010·Respiration; International Review of Thoracic Diseases·Julia TarregaJoaquin Sanchis
Feb 9, 2002·Chest·Folkert BrijkerHans Th M Folgering
Sep 15, 2009·Chest·Magnus EkströmKerstin E Ström
May 29, 2016·Sleep Medicine Clinics·Ronaldo A Sevilla Berrios, Peter C Gay
Jan 8, 2008·The Annals of Thoracic Surgery·Lars G SvenssonUNKNOWN Society of Thoracic Surgeons Endovascular Surgery Task Force
Jun 1, 2014·Revue des maladies respiratoires·C FuhrmanM-C Delmas
Feb 24, 2001·Clinics in Chest Medicine·G T Ferguson
Jun 9, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Josephine M CranstonAlan J Crockett
Jun 10, 2010·Circulation·Michael A CoadyUNKNOWN American Heart Association Council on Cardiovascular Surgery and Anesthesia and Council on Peripheral Vascular Disease
Oct 10, 2007·Hemodialysis International·Tushar J Vachharajani, Naveen K Atray
Dec 12, 2017·Current Opinion in Pulmonary Medicine·Faisal M Siddiqui, Joshua M Diamond
Jun 12, 2019·Annals of the American Thoracic Society·John M ColemanRavi Kalhan
Aug 31, 2019·The European Respiratory Journal·Begum ErganWolfram Windisch
Sep 19, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Luis Pérez de LlanoBorja G Cosio

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