Relative susceptibilities of C57BL/6, (C57BL/6 x C3H/He)F1, and C3H/He mice to acute toxicity and carcinogenicity of nickel subsulfide

Toxicology
R E RodriguezK S Kasprzak

Abstract

The aim of this study was to compare susceptibility of mice of different strains to the toxicity and carcinogenicity of nickel subsulfide (Ni3S2), a water insoluble compound suspected to damage cells through oxidative mechanisms. Groups of 30 male mice of each strain, C57BL/6 (C57BL), (C57BL x C3H/He)F1 (B6C3F1), and C3H/He (C3H), were injected with single doses of 0.5-10 mg of Ni3S2/site into the thigh muscle and observed for up to 78 weeks. The highest Ni3S2 dose was lethal within 1 week to C57BL (93%) > B6C3F1 (80%) > C3H (53%) mice. The most susceptible C57BL mice also had the most severe necrotic/inflammatory kidney damage, compared with that in the other mice. The final incidence of local sarcomas at the 5 mg Ni3S2 dose was: C3H (97%) > B6C3F1 (76%) > C57BL (40% of mice at risk, i.e. those surviving at least 25 week; P < 0.05 or better as compared to the incidence in C3H mice). The relatively highest acute toxicity of Ni3S2 in C57BL mice observed in the present study, concurred with the weakest antioxidant response to systemic water-soluble nickel(II), resulting in reduction in glutathione (GSH) level and increased lipid peroxidation (LPO) in their kidneys and livers, two main targets of acute nickel toxicity, reported by...Continue Reading

References

Nov 1, 1991·Chemical Research in Toxicology·C B KleinM Costa
Nov 1, 1991·Chemical Research in Toxicology·K S Kasprzak
Aug 1, 1971·Journal of Medical Microbiology·C R Amies, A Corpas
Aug 1, 1982·Journal of Inorganic Biochemistry·K Kuehn, F W Sunderman
Jan 1, 1995·Cancer Investigation·K S Kasprzak

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Citations

Feb 23, 2010·Environmental Science and Pollution Research International·Abel L G FerreiraSusana Loureiro
Dec 4, 2003·Mutation Research·Kazimierz S KasprzakKonstantin Salnikow
Jun 1, 2000·Journal of Inorganic Biochemistry·K S Kasprzak, K Bialkowski
Mar 30, 2002·Critical Reviews in Oncology/hematology·E Denkhaus, K Salnikow
Oct 4, 2006·Journal of the Royal Society, Interface·Torsten HansenC James Kirkpatrick
Jul 23, 2004·American Journal of Respiratory Cell and Molecular Biology
Apr 17, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gretchen N NeighA Courtney DeVries
Nov 13, 2004·Chemico-biological Interactions·Pardeep SidhuD K Dhawan
Feb 18, 2020·Metallomics : Integrated Biometal Science·Desmond I BannonRoger Abounader
Nov 1, 2007·Chemical Research in Toxicology·Konstantin Salnikow, Anatoly Zhitkovich

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