Relative susceptibilities of inbred mouse strains C57BL/6 and A/J to infection with Histoplasma capsulatum.

Infection and Immunity
B A Wu-Hsieh

Abstract

Differences in the 30-day survival of Histoplasma capsulatum after intravenous injection indicated that the A/J strain of inbred mouse was more resistant to experimental infection than was the C57BL/6 strain. CFU from the spleens of infected animals increased during the first week after injection but gradually declined over the next 3 weeks. The CFU per gram of tissue in the C57BL/6 animals were 10- to 100-fold higher than were those in the A/J mice during the time between 7 and 28 days after infection. The units of gamma interferon (IFN-gamma) in supernatants of spleen cells stimulated with heat-killed yeast cells of H. capsulatum reached a peak at the time of the largest number of CFU per gram of tissue. The titers of IFN-gamma at days 3 to 5 were higher in the A/J mice than they were in the C57BL/6 mice, but from days 7 to 28, the titers of IFN-gamma were not correlated with the more efficient clearance of the fungus from the spleens of A/J mice. The L3T4+ spleen cells were shown to be active IFN-gamma producers. Treatment of Histoplasma-infected mice with anti-IFN-gamma antibody resulted in much larger tissue burdens of the fungus in the lungs and spleens of treated animals than in untreated animals. There was no marked dif...Continue Reading

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Citations

Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·C F XidiehE Burger
Apr 14, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jamie H Rosenblum LichtensteinJoseph D Brain
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·J W MurphyI C Kowanko
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jr-Shiuan LinBetty A Wu-Hsieh
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B A Wu-HsiehR Ahmed
Apr 7, 1998·Infection and Immunity·J A Cain, G S Deepe
Aug 28, 1998·Research in Immunology·G S Deepe, R A Seder
Jul 1, 1997·Infection and Immunity·R Allendoerfer, G S Deepe
Feb 1, 1995·Infection and Immunity·J K ByronD A Stevens
Nov 1, 1993·The American Journal of the Medical Sciences·J K KollsW R Summer

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