PMID: 2497226May 1, 1989Paper

Relative V beta transcript levels in thymus and peripheral lymphoid tissues from various mouse strains. Inverse correlation of I-E and Mls expression with relative abundance of several V beta transcripts in peripheral lymphoid tissues

The Journal of Experimental Medicine
C Y Okada, I L Weissman

Abstract

We have measured the relative levels of transcripts for 15 of the 22 known V beta gene segments. The level of transcripts for the highest and lowest expressed V beta gene segment differed by greater than 20-fold in the thymus and an even larger difference was observed in the periphery. The levels of expressions were unrelated to the order of the V beta genes on the chromosome. For most of the V beta gene segments, the relative transcript levels were the same in the thymus and periphery, suggesting that thymic selection in general does not act solely upon the V beta gene segment. One V beta gene segment in the BALB and B10 mice strains was an exception to this rule. V beta 5.2 expression in the periphery of BALB and B10 mice inversely correlated with the expression of the MHC class II molecule I-E. Five V beta gene segments had reduced transcript levels in the periphery of Mls-1a mice compared with their thymic levels or to the levels found in Mls-1b mice. The peripheral level of V beta 3 transcripts vary with MHC and Mls-2 haplotypes. The observation that certain V beta transcript levels are reduced in the periphery when compared with the thymus favors the hypothesis that self tolerance at the T cell level results in the elimin...Continue Reading

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Citations

May 1, 1992·Journal of Clinical Immunology·C G Drake, B L Kotzin
Jun 1, 1991·Molecular Immunology·P J DohertyA Cohen
Oct 10, 1998·Immunology·M SutmullerJ A Bruijn
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R BaccalaA N Theofilopoulos
Feb 1, 1991·The Journal of Experimental Medicine·P V LehmannZ A Nagy
May 1, 1991·The Journal of Experimental Medicine·A M PullenJ W Kappler
Jul 1, 1991·The Journal of Experimental Medicine·A J Feeney
Jul 1, 1991·The Journal of Experimental Medicine·G RubertiA M Livingstone
Jun 1, 1992·The Journal of Experimental Medicine·W HeldH Acha-Orbea
Nov 1, 1993·The Journal of Experimental Medicine·R RajasekarA Augustin
May 1, 1990·Scandinavian Journal of Immunology·A M WegenerB Rubin
Dec 1, 1990·Immunological Reviews·P A Singer, A N Theofilopoulos
Feb 1, 1993·Immunological Reviews·H Acha-OrbeaH R MacDonald
Jan 1, 1992·International Reviews of Immunology·D L Woodland, M A Blackman
Jan 1, 1992·International Reviews of Immunology·H Acha-OrbeaA N Shakhov
Jan 1, 1995·International Reviews of Immunology·R González-QuintialA N Theofilopoulos
Feb 3, 1997·The Journal of Experimental Medicine·M DelcourtR P Sekaly
Feb 2, 2000·International Immunology·L FahlénC L Sentman
Apr 25, 2008·Current Protocols in Immunology·Howard A YoungStephanie M Krebs
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F ChenE V Rothenberg
Oct 1, 1992·European Journal of Immunology·M CochetP Kourilsky
Mar 1, 1992·European Journal of Immunology·L R SmithA N Theofilopoulos
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P Sieh, J Chen

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