Relatively high biliary secretory maximum for non-micelle-forming bile acid: possible significance for mechanism of secretion

Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society
E R O'Maille, A F Hofmann

Abstract

Because of the formation of mixed micelles, the effective (i.e. monomeric, intermicellar) concentration of bile acid in bile is only a small fraction of the total concentration: this factor could be of critical importance for the net hepatic transport of the natural bile acids (especially transport across the canalicular membrane, which is hypothesized to be passive). To assess the influence of micelle formation on bile acid secretion, the rate-limiting canalicular transport of the natural, micelle-forming bile acid, cholyltaurine, was compared with that of the artificial non-micelle-forming bile acid, dehydrocholyltaurine (which undergoes partial reductive metabolism), in the anaesthetized rat with a bile fistula. The derivatives of dehydrocholyltaurine shared the same biliary transport system as cholyltaurine and had a secretory maximum (22 +/- 4.7 (S.D.) mumol/min . kg, n = 12) which was significantly greater than that of cholyltaurine (15 +/- 1.2, n = 6) (P less than 0.01). The biliary secretion rates of phospholipid and cholesterol during maximal secretion of dehydrocholyltaurine derivatives were not raised over control values; 3 alpha-hydroxy, 7,12-dioxocholanoate (the taurine conjugate of which accounted for about 70-80%...Continue Reading

Citations

Dec 1, 1989·Digestive Diseases and Sciences·A F Hofmann
Nov 15, 1989·Biochemical Pharmacology·M G RomaE A Rodrguez Garay
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M Crawford, J L Gollan
Feb 19, 2000·Biochemical and Biophysical Research Communications·H JaegerF Berr

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