Relatively low primary drug resistant tuberculosis in southwestern Ethiopia.

BMC Research Notes
Gemeda AbebeRobert Colebunders

Abstract

The prevalence of drug resistant tuberculosis (TB) in Ethiopia in general, and Jimma area in particular, is not well documented. We conducted a study at Jimma University specialized hospital in southwest Ethiopia among new cases of smear positive TB patients to determine the pattern of resistance to first-line drugs. A health institution based cross sectional study was conducted from November 2010 to September 2011. Any newly diagnosed smear positive TB patient 18 years and above was included in the study. Demographic and related data were collected by trained personnel using a pretested structured questionnaire. Mycobacterial drug susceptibility testing (DST) to the first line drugs isoniazid (INH), rifampicin (RIF), ethambutol (EMB) and streptomycin (STM) was performed on cultures using the indirect proportion method. M. tuberculosis complex (MTBC) was identified with the Capilia TB-Neo test. 136 patients were enrolled in the study. Resistance to at least one drug was identified in 18.4%. The highest prevalence of resistance to any drug was identified against INH (13.2%) followed by STM (8.1%). There was no statistically significant difference in the proportion of any resistance by sex, age, HIV status and history of being im...Continue Reading

References

Nov 1, 2006·Emerging Infectious Diseases·Eva NathansonMario C Raviglione
May 16, 2008·FEMS Immunology and Medical Microbiology·Amita Jain, Rajesh Mondal
Feb 28, 2009·The Lancet Infectious Diseases·Evan W OrensteinAlison P Galvani
Dec 13, 2012·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M DaraUNKNOWN International Union Against Tuberculosis and Lung Disease

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Citations

Sep 7, 2013·BMC Research Notes·Bereket WorkalemahuAbraham Aseffa
Jun 1, 2016·International Journal of Mycobacteriology·Mulualem TadesseGemeda Abebe
Sep 4, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Girma MulisaGodana Jarso
Feb 17, 2015·Antimicrobial Resistance and Infection Control·Fantahun BiadglegneArne C Rodloff
Jun 1, 2018·Journal of Pathogens·Solomon Weldegebreal AsgedomHailay Gebreyesus
Aug 31, 2019·Advances in Preventive Medicine·Alemayehu RetaAbeba Mengist

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Software Mentioned

SPSS
Capilia

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