PMID: 11319652Apr 25, 2001Paper

Relatively low serum leptin levels in adults born with intra-uterine growth retardation

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
D JaquetClaire Levy-Marchal

Abstract

In-utero under-nutrition dramatically alters the development of adipose tissue, during the fetal and the neonatal period. To investigate whether adults born with intra-uterine growth retardation (IUGR) show evidence of impaired adipose tissue development and leptin regulation. Serum leptin concentrations were measured in 26 healthy adults born with IUGR and 25 controls aged 24 y who have been studied previously, 3 y ago. The IUGR group demonstrated a significant increase of body mass index (BMI) in comparison to controls between 21 and 24 y of age (4.8+/-7.7%, P=0.004 vs 0.8+/-6.7%, P=0.70). Percentage of total body fat mass was significantly higher in IUGR-born subjects than in controls (27.2+/-7.6 vs 22.0+/-7.3%, P=0.02). Fasting insulin was significantly higher in the IUGR group (7.5+/-3.8 vs 5.3+/-2.3 miccroU/ml, P=0.03). Surprisingly, crude serum leptin concentrations did not significantly differ between the two groups. Moreover, adjusted means of serum leptin levels were significantly lower in IUGR-born subjects than in controls when corrected for body fat mass, gender and fasting insulin (11.3 vs 13.8 ng/ml, P=0.02). Adults born with IUGR developed an excess of adipose tissue associated with relatively low serum leptin l...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Oct 1, 1987·The American Journal of Clinical Nutrition·H C Lukaski
May 1, 1993·Acta Paediatrica·K Albertsson-WiklandS Rosberg
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M F SaadV Kamdar
Apr 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·F LönnqvistP Arner
May 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S M HaffnerM Laakso
Aug 1, 1997·Endocrinology·W I SivitzW G Haynes
Sep 1, 1997·The Journal of Clinical Investigation·G BodenM Polansky
Apr 29, 1998·The Journal of Clinical Endocrinology and Metabolism·D JaquetP Czernichow
Mar 27, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R B CeddiaR Curi
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·D JaquetC Levy-Marchal
Nov 11, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D I PhillipsP C Owens
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·D JaquetC Levy-Marchal

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Citations

Dec 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Janna L MorrisonIsabella C McMillen
Mar 20, 2003·Current Diabetes Reports·Delphine JaquetClaire Levy-Marchal
Mar 12, 2004·Seminars in Neonatology : SN·Claire Levy-MarchalPaul Czernichow
Jun 1, 2012·Journal of Developmental Origins of Health and Disease·A K PortellaP P Silveira
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Paul L HofmanWayne S Cutfield
May 11, 2006·Hormone Research·P L HofmanW S Cutfield
Jul 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Taly MeasClaire Levy-Marchal
Jun 10, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Jacques Beltrand, Claire Lévy-Marchal
Jun 28, 2008·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J Beltrand, C Lévy-Marchal
Sep 29, 2004·Pediatric Diabetes·Claire Levy-Marchal, Delphine Jaquet
Nov 6, 2007·Clinical Endocrinology·Feyza DarendelilerNurten Eskiyurt
Dec 18, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·L M A Shaw, S Elton
Jun 17, 2005·Annales d'endocrinologie·M-A Charles
Mar 22, 2014·Annals of the New York Academy of Sciences·André Krumel Portella, Patrícia Pelufo Silveira
May 5, 2016·Cardiovascular Diabetology·François R JornayvazPedro Marques-Vidal
Nov 4, 2005·Biology of Reproduction·Michael C Henson, V Daniel Castracane
Dec 19, 2003·Pediatric Research·Tracey A M HarringtonJimmy D Bell
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Li ChenB L G Nyomba
Mar 19, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Katherine C B SharrockThomas W McDade
Nov 10, 2010·Clinical Neuropharmacology·Ganesan VenkatasubramanianBangalore N Gangadhar
May 13, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J BoikoC Lévy-Marchal
Oct 19, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D JaquetC Lévy-Marchal
Feb 27, 2007·Endocrine Reviews·Paul SaengerEdward O Reiter
Mar 1, 2006·Expert Review of Endocrinology & Metabolism·Wayne S CutfieldMark A Sperling
Feb 15, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jaime A DuffieldI Caroline McMillen
Mar 13, 2014·American Journal of Physiology. Endocrinology and Metabolism·Kathryn L GatfordGlenn K McConell
Oct 27, 2017·Seminars in Immunopathology·Kristin ThielePetra Clara Arck
Nov 21, 2019·Acta Paediatrica·Anna Kistner
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard A EhrhardtYves R Boisclair
Dec 4, 2003·The Journal of Nutrition·Richard A EhrhardtYves R Boisclair
May 1, 2006·Expert Review of Endocrinology & Metabolism·Rasa VerkauskieneClaire Lévy-Marchal
Mar 3, 2020·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ann HellströmAnna Kistner

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