Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles

European Journal of Pharmacology
Sergio BovaF Fusi


We have investigated the effects of the rat-specific vasoconstrictor agent norbormide on the mechanical and electrophysiological properties of rat non-vascular smooth muscles. Norbormide (50 microM) did not affect the resting tone of urinary bladder, tracheal, and duodenal rings. In all tissues, KCl-induced concentration-response curves were shifted downward by norbormide (5 and 50 microM). In urinary bladder and tracheal rings, norbormide inhibited contractile responses to carbachol only at the higher concentration (50 microM). In single gastric fundus myocytes, 50 microM norbormide inhibited L-type Ca(2+) current (I(Ca(L))) by about 60%, neither affecting both activation and inactivation rates of the current nor the current-voltage curve along the voltage axis. Our results indicate that rat non-vascular smooth muscles are relaxed by norbormide with a mechanism likely involving a reduction of Ca(2+) entry through L-type Ca(2+) channels.


Apr 1, 1985·British Journal of Pharmacology·F AhmedR C Small
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·F S Fay, C M Delise
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Oct 1, 1982·Pflügers Archiv : European journal of physiology·G Isenberg, U Klockner
Sep 16, 2000·European Journal of Pharmacology·K SatoH Karaki

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