Relaxant effect of ethanol extract of Carum carvi on dispersed intestinal smooth muscle cells of the guinea pig

Pharmaceutical Biology
Mohammed K Al-EssaFatma U Afifi

Abstract

The present study investigates the direct effects of Carum carvi L. (Apiaceae) ethanol extract on dispersed intestinal smooth muscle cells (SMC) of guinea pigs. Effects of the plant extract on SMC and of acetylcholine (Ach) on extract pretreated SMC were measured by micrometric scanning technique. Three different extract concentrations (2.5 mg/mL, 250 mug/mL, and 25 mug/mL) were used. Ethanol extract of C. carvi reduced significantly the response of dispersed SMC to Ach. Pretreatment of SMC with the highest concentration of C. carvi ethanol extract (2.5 mg/mL) has significantly inhibited the response of SMC to Ach. The data obtained indicate a dose-dependent inhibition of the contraction induced by Ach. This response may explain, in part, the beneficial effect of caraway in relieving gastrointestinal symptoms associated with dyspepsia.

References

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Citations

Nov 19, 2011·Pharmacognosy Reviews·R K Johri
Apr 18, 2015·Pharmaceutical Biology·Krystyna Skalicka-WoźniakNatalia Dziekan
Jul 12, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G RichG Holtmann
Feb 1, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S BotschuijverR M van den Wijngaard
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona Codruta HeghesLorena Filip
Oct 16, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Dagmar KruegerMichael Schemann
May 8, 2018·Wiener medizinische Wochenschrift·Ahmed MadischStephan Köhler

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