Relaxant effect of the ethanol extract of Helichrysum plicatum (Asteraceae) on isolated rat ileum contractions.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Dubravka BigovicSlavoljub Zivanovic

Abstract

Helichrysum plicatum (Turkish Helichrysum) has been used in folk medicine for the treatment of gastric and hepatic disorders. The aim of the present study was to examine the relaxant activity of an extract of H. plicatum flowers on isolated rat ileum. Segments of ileum of rats were suspended in an organ bath. Cumulative concentrations of H. plicatum ethanol extract induced a relaxant effect on spontaneous rat ileum contractions. H. plicatum extract caused a mean contractile response of 81.68 +/- 6.17% (at a dose of 0.01 mg/mL) and 30.08 +/- 9.07% (at a dose of 1 mg/mL). A similar effect was observed with papaverine (0.01-3 microg/mL). H. plicatum extract (0.01-1 mg/mL) relaxed high K+ (80 mM) precontractions, an effect similar to that caused by papaverine (0.01-3 microg/mL). The plant extract (0.03-0.3 mg/mL) also induced a significant depression of the cumulative concentration response curve for acetylcholine (5-1500 nM) (p < 0.01). Atropine (140 nM) abolished the acetylcholine effect. The extract (0.03-0.3 mg/mL) reduced the histamine (1-300 nM) and BaCl2 (3-900 microM) induced contractions (p < 0.01). Our results showed the relaxant effect of the ethanol extract of Helichrysum plicatum flowers on the isolated rat intestine E...Continue Reading

References

Aug 1, 1986·British Journal of Pharmacology·H KarakiS Shibata
Apr 1, 1995·Journal of Ethnopharmacology·V R Sánchez de RojasA Villar
Apr 25, 1996·The New England Journal of Medicine·R K Goyal, I Hirano
Apr 1, 1996·Planta medica·A RojasR Mata
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J M HemmingG M Mawe
Nov 25, 2000·Journal of Ethnopharmacology·E CzinnerE Lemberkovics
Mar 22, 2003·Journal of Ethnopharmacology·Canan Karamenderes, Sebnem Apaydin
Jan 13, 2006·British Journal of Pharmacology·Victoria Boswell-SmithClive P Page
Apr 19, 2006·Phytotherapy Research : PTR·M RadenkovicS Veljkovic
Nov 2, 2006·Basic & Clinical Pharmacology & Toxicology·Anwarul Hassan GilaniJoachim W Herzig
Feb 15, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·H Fleer, E J Verspohl
Jun 28, 2008·Journal of Ethnopharmacology·Francisco Palacios-EspinosaRachel Mata
Jul 16, 2009·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Takayuki MatsumotoYoshiyuki Seyama

❮ Previous
Next ❯

Citations

Jun 15, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriela Lemos de Azevedo MaiaJosé Maria Barbosa-Filho
Aug 23, 2018·Frontiers in Plant Science·Dejan PljevljakušićKatarina Šavikin
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hao WuHongbin Xiao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.