Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanism(s)

Journal of Ethnopharmacology
Mohammad Hossein BoskabadyH Rakhshandah

Abstract

Several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of Rosa damascena. Therefore in the present study, the relaxant effects of ethanolic extract and essential oils of Rosa damascena on tracheal chains of guinea pigs were examined. The relaxant effects of four cumulative concentrations of ethanolic extract (0.25, 0.5, 0.75, and 1.0g%) and essential oils (0.25, 0.5, 0.75, and 1.0vol.%) in comparison with saline as negative control and four cumulative concentrations of theophylline (0.25, 0.5, 0.75, and 1.0mM) were examined by their relaxant effects on precontracted tracheal chains of guinea pig by 60mM KCl (group 1, n=5) and 10microM methacholine in two different conditions including: non-incubated tissues (group 2, n=8) and incubated tissues with 1microM propranolol and 1microM chlorpheniramine (group 3, n=5). In group 1 experiments two final concentrations of essential oil and theophylline and only final concentration of ethanolic extract showed relaxant effects compared to that of saline (p<0.01-0.001). In group 2 three higher concentrations of ethanolic extract and theophylline and all concentrations of essential o...Continue Reading

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Citations

Oct 26, 2013·Journal of Ethnopharmacology·Mohammad Hossein BoskabadySediqeh Jalali
Oct 18, 2012·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Murat AyanFeridun Koyuncu
Mar 26, 2008·Journal of Medicinal Food·Mahtab JafariThomas Wang
Oct 1, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Suresh AwaleShigetoshi Kadota
May 22, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Mohammad Hossein BoskabadyMorteza Boskabady
Apr 11, 2014·Iranian Red Crescent Medical Journal·Soheila BaniMorteza Gojazadeh
Feb 13, 2016·Journal of Traditional and Complementary Medicine·Mohaddese Mahboubi
Apr 22, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A GholamhoseinianF Sharifi far
Oct 13, 2015·Journal of Ethnopharmacology·Farzaneh Shakeri, Mohammad Hossein Boskabady
Aug 11, 2007·Physiology & Behavior·B F BradleyR W Lea
Oct 17, 2015·Iranian Red Crescent Medical Journal·Shirin FahimiMohammad Amin Rezvanfar
Feb 17, 2015·International Journal of Pharmaceutics·A El AsbahaniA Elaissari
May 28, 2014·Pharmaceutical Biology·Mahmoodreza MoeinShiva Delnavaz
Dec 17, 2014·BMC Complementary and Alternative Medicine·Niaz AliMuhammad Junaid
May 27, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Hossein Karegar-BorziRoja Rahimi
Jan 2, 2016·Journal of Evidence-based Complementary & Alternative Medicine·Arshiya SultanaQ N Qhuddsia
Aug 23, 2018·Phytotherapy Research : PTR·Zahra GholamnezhadMohammad Hossein Boskabady
Sep 24, 2013·Natural Product Reports·Aikaterini ArgyropoulouAlexios-Leandros Skaltsounis
Jun 11, 2015·Phytotherapy Research : PTR·Arif-Ullah Khan, Anwarul-Hassan Gilani
Dec 17, 2020·Frontiers in Pharmacology·Roodabeh Bahramsoltani, Roja Rahimi
Mar 13, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Tariq Nadeem KhanTasfiya Hakeem Ansari

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