Relaxant effects of the soluble guanylate cyclase activator and NO sensitizer YC-1 in piglet pulmonary arteries

Biology of the Neonate
Gema González-LuisEduardo Villamor

Abstract

The indazole derivative YC-1 has been characterized as a nitric oxide (NO)-independent and heme dependent soluble guanylate cyclase (sGC) activator, which also sensitizes sGC to NO. To examine the effects of YC-1 on vascular relaxation in newborn and 2-week-old piglet pulmonary arteries. The effect of YC-1 on the relaxation induced by exogenous NO was also analyzed. Isolated rings from third branch pulmonary arteries and fifth-seventh-generation intrapulmonary arterioles were mounted in organ chambers for isometric tension recording. Arteries were precontracted with the thromboxane A2 mimetic U46619. YC-1 induced relaxation was greater in 2-week-old pulmonary arteries and was abolished by the sGC inhibitor ODQ (10 microM). YC-1 induced relaxation was similar in conduit pulmonary arteries and arterioles. In the 2-week-old conduit pulmonary arteries, the response to YC-1 was significantly reduced when the endothelium was removed or after incubation with the NO synthase inhibitor L-NAME (0.1 mM). YC-1 augmented NO-induced relaxation in 2-week-old but not in neonatal conduit pulmonary arteries. Our results indicate that YC-1 induced pulmonary vascular relaxation in conduit and resistance pulmonary arteries and these effects increas...Continue Reading

References

Jun 1, 1992·British Journal of Pharmacology·S F LiuP J Barnes
Aug 1, 1991·Pediatric Research·T M Zellers, P M Vanhoutte
Jul 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·A A HislopS G Haworth
Jan 1, 1994·Advances in Pharmacology·T D WarnerF Murad
Jan 28, 1998·Molecular Pharmacology·A Friebe, D Koesling
Feb 26, 2000·Cardiovascular Research·P J BoelsS G Haworth
Oct 4, 2000·Physiological Reviews·V Hampl, J Herget
Dec 19, 2000·Biochemical and Biophysical Research Communications·D A TulisA I Schafer
Mar 10, 2001·Nature·J P StaschM Schramm
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eduardo VillamorCarlos E Blanco
May 7, 2002·Life Sciences·F I ArrigoniJ A Mitchell
Sep 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Francisco Pérez-VizcaínoJuan Tamargo
Oct 2, 2002·Lancet·Hossein Ardeschir GhofraniFriedrich Grimminger
Jul 26, 2003·Circulation Research·Andreas Friebe, Doris Koesling
Sep 28, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura MorenoFrancisco Perez-Vizcaino

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