Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus

European Journal of Pharmacology
A J Barbier, Romain A Lefebvre

Abstract

The breakdown of the relaxation-inducing second messengers cAMP and cGMP is mediated by phosphodiesterases. Inhibitors of functionally present phosphodiesterases can be expected to induce relaxation by increasing the basic amount of cAMP and/or cGMP. In the cat gastric fundus, vinpocetine, which has some selectivity for phosphodiesterase type I, only induced contractions, but the inhibitors of type III [5-(4-acetimidophenyl)pyrazin-(1H)-one; SKF 94120], type IV (rolipram) and type V (zaprinast) phosphodiesterase all caused concentration-dependent relaxation, as did the non-specific phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). The most potent relaxant agent was rolipram (EC50 9 +/- 5 x 10(-7) M and 3 +/- 1 x 10(-7) M in longitudinal and circular smooth muscle strips, respectively). These results suggest that type III, IV and V phosphodiesterases are functionally present in the cat gastric fundus and are involved in the regulation of tone. The possible influence of the phosphodiesterase inhibitors on non-adrenergic non-cholinergic (NANC) relaxation induced by nitric oxide (NO), vasoactive intestinal polypeptide (VIP) and train and sustained electrical field stimulation was then tested. Rolipram (3 x 10(-8) M), ...Continue Reading

References

Apr 1, 1990·Trends in Pharmacological Sciences·J A Beavo, D H Reifsnyder
Jun 1, 1990·Circulation Research·M Kelm, J Schrader
Nov 1, 1987·British Journal of Pharmacology·S E Bryson, I W Rodger
Jan 1, 1989·Molecular Neurobiology·I Gozes, D E Brenneman

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Citations

Aug 17, 1999·European Journal of Pharmacology·K O'Kane, A Gibson
Mar 6, 2002·British Journal of Pharmacology·Juan V Esplugues
May 2, 2002·Acta Physiologica Scandinavica·M StorrH D Allescher
May 29, 2008·Clinical and Experimental Pharmacology & Physiology·H A ArabA Bozorgi
Feb 8, 2006·Journal of Gastroenterology and Hepatology·Seung Hyun ChoJeffrey L Conklin
Oct 1, 1995·British Journal of Pharmacology·R A LefebvreJ P Timmermans
Oct 17, 2014·The Journal of Veterinary Medical Science·Takeharu KanedaKazumasa Shimizu
Apr 25, 2006·British Journal of Pharmacology·Francesca BorrelliAngelo A Izzo
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C SeveriG Delle Fave
Oct 11, 2008·Fundamental & Clinical Pharmacology·Theophano A PsarraMaria Koutsoviti-Papadopoulou
Jul 18, 2002·The Journal of Surgical Research·Brian A LindamanJoseph J Cullen

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