PMID: 7537594Feb 1, 1995Paper

Relaxation and decrease in [Ca2+]i by hydrochlorothiazide in guinea-pig isolated mesenteric arteries

British Journal of Pharmacology
P Pickkers, A D Hughes

Abstract

1. We examined the effect of the thiazide diuretic, hydrochlorothiazide, on on intracellular calcium concentration ([Ca2+]i) and tone in guinea-pig mesentery arteries. Vessels were mounted on a microvascular myograph and loaded with the Ca(2+)-sensitive fluorescent dye, Fura-2. 2. Hydrochlorothiazide caused relaxation of noradrenaline-precontracted arteries associated with a fall in [Ca2+]i. Preincubation of arteries with hydrochlorothiazide inhibited both contraction and rise in [Ca2+]i in response to noradrenaline. Hydrochlorothiazide did not affect tone and [Ca2+]i when this was elevated by a combination of depolarizing potassium solution and noradrenaline. 3. Hydrochlorothiazide-induced vasorelaxation and decrease of [Ca2+]i was abolished by charybdotoxin, a blocker of large conductance Ca(2+)-activated K channels. 4. The rise in [Ca2+]i elicited by caffeine in Ca(2+)-free physiological salt solution, and presumably reflecting Ca2+ release from intracellular stores, was not altered by preincubation with hydrochlorothiazide. 5. Under depolarizing conditions hydrochlorothiazide did not alter the relationship between the extracellular concentration of Ca2+ and [Ca2+]i; however, hydrochlorothiazide caused a small reduction in t...Continue Reading

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Citations

Jan 1, 1996·Pharmacology & Therapeutics·K Lawson
Nov 9, 2000·European Journal of Pharmacology·B ColasM Andrejak
Feb 13, 2001·British Journal of Pharmacology·P PickkersP Smits
Jul 1, 2009·Hypertension·David H Ellison, Johannes Loffing
Feb 14, 2016·Current Opinion in Pharmacology·Mohamed H Shahin, Julie A Johnson
Feb 11, 2004·British Journal of Pharmacology·E E M van GinnekenG A Rongen
Mar 24, 2016·Sexual Medicine·Thiago Gagliano-JucáGilberto De Nucci
Jul 27, 2001·Fundamental & Clinical Pharmacology·L GalánJ L Alvarez
Apr 2, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Alun D Hughes
Nov 25, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Robert M RapoportManoocher Soleimani
Sep 24, 2019·Frontiers in Pharmacology·Robert M Rapoport, Manoocher Soleimani

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