Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle

European Journal of Pharmacology
P DevillierG Bessard

Abstract

Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides were investigated in epithelium-denuded guinea pig tracheal rings, treated with indomethacin (5 microM) and phosphoramidon (1 microM) and contracted with histamine (3 microM). Atrial natriuretic peptide (ANP) was a more potent relaxant than C-type natriuretic peptide whereas ANP-(4-23) was inactive suggesting the involvement of ANP(A) receptors in the relaxant effect of ANP. ODQ (1H-[1,2,4]oxadiazolo[4,3-A]quinoxalin-1-one, 10 microM), a selective inhibitor of soluble guanylyl cyclase, markedly inhibited the relaxant response to sodium nitroprusside. The relaxant response to ANP was not altered by ODQ demonstrating the involvement of particulate guanylyl cyclase. ANP-induced relaxations, as well as sodium nitroprusside-induced relaxations, were similarly potentiated by rolipram (4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one, 3 microM), a type IV phosphodiesterase inhibitor, and by zaprinast (2-(2-propyloxyphenyl)-8-azapurin-6-one, 10 microM), a type V phosphodiesterase inhibitor. ANP-mediated response was unaffected by glibenclamide (10 microM), a selective blocker of ATP-sensitive K(+) channels, and by apamin (1 microM), a se...Continue Reading

References

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Citations

Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Gary HellermannShyam S Mohapatra
Sep 12, 2002·European Journal of Pharmacology·Timothy J Martin, K J Broadley
Mar 18, 2011·British Journal of Pharmacology·Maria G MateraAugusto Orlandi
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T IshikawaK Shimokata
Mar 24, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yasushi MakinoKaichiro Kamiya
May 18, 2004·European Journal of Pharmacology·Katsuo KoikeYoshio Tanaka
Oct 11, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ahmed M HamadA J Knox

Related Concepts

Iberiotoxin
Atrial natriuretic factor (102-121), Tyr(3)-des(Gln(116)-Ser(117)-Gly(118)-Leu(119)-Gly(120))-
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one
Cyclic AMP, (R)-Isomer
Adenylate Cyclase
Metazoa
Apamin
Dose-Response Relationship, Drug
Enzyme Activation
Enzyme Inhibitors

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