Relaxation-compensated CEST-MRI of the human brain at 7T: Unbiased insight into NOE and amide signal changes in human glioblastoma

NeuroImage
Moritz ZaissAlexander Radbruch

Abstract

Endogenous chemical exchange saturation transfer (CEST) effects of protons resonating near to water protons are always diluted by competing effects such as direct water saturation and semi-solid magnetization transfer (MT). This leads to unwanted T2 and MT signal contributions that contaminate the observed CEST signal. Furthermore, all CEST effects appear to be scaled by the T1 relaxation time of the mediating water pool. As MT, T1 and T2 are also altered in tumor regions, a recently published correction algorithm yielding the apparent exchange-dependent relaxation AREX, is used to evaluate in vivo CEST effects. This study focuses on CEST effects of amides (3.5ppm) and Nuclear-Overhauser-mediated saturation transfer (NOE, -3.5ppm) that can be properly isolated at 7T. These were obtained in 10 glioblastoma patients, and this is the first comprehensive study where AREX is applied in human brain as well as in human glioblastoma. The correction of CEST effects alters the contrast significantly: after correction, the CEST effect of amides does not show significant contrast between contrast enhancing tumor regions and normal tissue, whereas NOE drops significantly in the tumor area. In addition, new features in the AREX contrasts are...Continue Reading

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Citations

Feb 10, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patrick SchuenkeMoritz Zaiss
Feb 5, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Moritz ZaissAlexander Radbruch
Oct 8, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiang XuJiadi Xu
Jun 27, 2015·Neuro-oncology·Robert J HarrisBenjamin M Ellingson
Jul 30, 2015·Clinical Neuroradiology·A Radbruch, M Bendszus
Apr 12, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vitaliy KhlebnikovHans Hoogduin
Mar 20, 2015·NMR in Biomedicine·Johannes WindschuhPeter Bachert
May 27, 2015·NMR in Biomedicine·Steffen GoerkePeter Bachert
Feb 11, 2016·Investigative Radiology·Elisabeth SpringerSiegfried Trattnig
Aug 4, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anja Müller-LutzHans-Jörg Wittsack
Aug 27, 2016·EJNMMI Physics·B WuG Delso
Oct 21, 2016·Journal of Magnetic Resonance·Vitaliy KhlebnikovHans Hoogduin
Jul 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vitaliy KhlebnikovOlivier Mougin
Mar 1, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Desmond H Y TseN Jon Shah
May 26, 2017·NMR in Biomedicine·Yuanyu ShenRenhua Wu
Feb 9, 2017·Scientific Reports·Patrick SchuenkeMoritz Zaiss
Nov 21, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vitaliy KhlebnikovHans Hoogduin
May 8, 2018·Journal of Magnetic Resonance Imaging : JMRI·Stefanie C ThustMarion Smits
Oct 17, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Iris Yuwen ZhouPhillip Zhe Sun
Jul 6, 2018·NMR in Biomedicine·Helge Jörn ZöllnerHans-Jörg Wittsack
Jul 31, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Iris Yuwen ZhouPhillip Zhe Sun
Aug 23, 2018·Journal of Magnetic Resonance Imaging : JMRI·Constantin DreherDaniel Paech
Sep 9, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai HerzMoritz Zaiss
Nov 16, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anagha DeshmaneKlaus Scheffler
Feb 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Moritz ZaissKlaus Scheffler
Mar 31, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steffen GoerkePeter Bachert
Apr 20, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andrzej LiebertArmin M Nagel
Jun 23, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rachel W ChanAngus Z Lau
Jul 31, 2019·NMR in Biomedicine·Johannes BreitlingMoritz Zaiss
Aug 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Or PerlmanChristian T Farrar
Aug 10, 2017·Journal of Magnetic Resonance Imaging : JMRI·Kyle M JonesMark D Pagel
Sep 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ferdinand ZimmermannSteffen Goerke
Dec 11, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix GlangMoritz Zaiss

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