Relaxation Editing Using Long-Lived States and Coherences for Analysis of Mixtures

Analytical Chemistry
Maninder SinghNarayanan D Kurur

Abstract

Nuclear magnetic resonance (NMR) is a powerful tool for structural and dynamical studies of molecules. Although widely applicable, the search for novel spectral editing methods that facilitate spectral assignment of peaks in high-resolution NMR is highly desirable. Earlier, the sensitivity of lifetime of spin states (spin-lattice relaxation time, T1) and coherences (spin-spin relaxation time, T2) to the immediate environment was utilized for spectral editing in solution NMR. Long-lived states (LLS) and coherences (LLCs) were recently uncovered to have longer and more domain sensitive lifetime than other type of states and coherences. Herein, this longevity and increased sensitivity of LLS and LLC lifetime is utilized for more enhanced dispersion in relaxation editing in NMR. The generality of the method as a powerful tool in spectral editing is confirmed with molecules containing a mixture of strongly and weakly coupled spin systems and finally with metabolomic mixture. Extension to insensitive nuclei enhanced by polarization transfer (INEPT), correlation spectroscopy (COSY), and heteronuclear single quantum coherence (HSQC) are also demonstrated.

References

Jun 1, 1983·The Biochemical Journal·J K NicholsonP J Sadler
Dec 16, 1983·Biochemical and Biophysical Research Communications·M RanceK Wüthrich
Mar 1, 1995·Analytical Chemistry·J K NicholsonJ C Lindon
Aug 12, 2004·Chemical Reviews·Arthur G Palmer
Jan 11, 2007·Journal of the American Chemical Society·Riddhiman SarkarGeoffrey Bodenhausen
Oct 9, 2007·The Journal of Chemical Physics·Puneet AhujaGeoffrey Bodenhausen
Aug 30, 2008·Journal of the American Chemical Society·Giuseppe PileioMalcolm H Levitt
Apr 7, 2010·Physical Review Letters·Riddhiman SarkarGeoffrey Bodenhausen
Jul 10, 2010·Journal of Magnetic Resonance·Aurélien BornetGeoffrey Bodenhausen
Oct 12, 2010·Natural Product Reports·Ramon Novoa-CarballalRicardo Riguera
May 24, 2011·Progress in Nuclear Magnetic Resonance Spectroscopy·Riddhiman SarkarGeoffrey Bodenhausen
Jun 15, 2011·The Journal of Chemical Physics·G Pileio
Sep 2, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Aurélien BornetPaul R Vasos
Jan 10, 2012·Annual Review of Physical Chemistry·Malcolm H Levitt
Jun 13, 2012·Journal of the American Chemical Society·Nicola SalviGeoffrey Bodenhausen
Jul 28, 2013·Journal of the American Chemical Society·Luiz F PintoEduardo Fernandez-Megia
Oct 24, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Maninder SinghNarayanan D Kurur
Sep 10, 2014·ChemMedChem·Roberto BurattoGeoffrey Bodenhausen

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Citations

Apr 11, 2017·Analytical Chemistry·Eva MonteagudoMíriam Pérez-Trujillo
Feb 27, 2021·Progress in Nuclear Magnetic Resonance Spectroscopy·Florin TeleanuPaul R Vasos
Mar 14, 2019·The Journal of Physical Chemistry Letters·Thomas KressDennis Kurzbach
Oct 28, 2016·The Journal of Physical Chemistry. B·Alexey S KiryutinKonstantin L Ivanov
Nov 5, 2019·The Journal of Physical Chemistry Letters·Rituraj MishraNarayanan D Kurur

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