Relaxation of cat trachea by beta-adrenoceptor agonists can be mediated by both beta1- and beta2-adrenoceptors and potentiated by inhibitors of extraneuronal uptake

British Journal of Pharmacology
S R O'Donnell, J C Wanstall

Abstract

1--Responses (relaxation) to the beta-adrenoceptor agonists, isoprenaline, fenoterol or noradrenaline, were obtained on cat tracheal preparations contracted with a submaximal concentration of carbachol (0.5 microM). 2--The relative potencies of isoprenaline: fenoterol: noradrenaline were 100:8.1:10.7. From this, it was concluded that responses were mediated predominantly by beta 1-adrenoceptors but that a minor population of beta 2-adrenoceptors might also be involved. 3--Schild plots for the selective antagonists atenolol (beta 1-selective) or ICI 118,551 (beta 2-selective) were in different locations, i.e. were separated, depending on whether the antagonist was antagonizing noradrenaline or fenoterol. This supported the conclusion that beta 2- as well as beta 1-adrenoceptors were involved in mediating the response. In this respect, cat trachea resembles cat atria (rate responses). 4--In the presence of atenolol the concentration-response curves to fenoterol became biphasic. This was interpreted as indicating that the beta 2-adrenoceptors were too few in number to elicit a maximum tissue response. 5--Responses to isoprenaline of cat trachea were potentiated by the extraneuronal uptake inhibitor drugs, corticosterone and metane...Continue Reading

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Citations

Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J J Cole, S R O'Donnell
Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
Sep 1, 1991·Journal of Veterinary Pharmacology and Therapeutics·C Ingvast-Larsson
Jun 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·K TörnekeL E Appelgren
Jan 1, 1990·British Journal of Pharmacology·P J Henry, R G Goldie
May 1, 1989·The Journal of Pharmacy and Pharmacology·M L Candenas, E Anselmi
Apr 1, 1984·British Journal of Pharmacology·S R O'Donnell, J C Wanstall
Feb 1, 1985·British Journal of Pharmacology·L C Blaber, A D Fryer
Feb 1, 1985·British Journal of Pharmacology·M L Hartley, J N Pennefather
Jun 25, 2004·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshio TanakaKatsuo Koike
Apr 1, 1984·British Journal of Pharmacology·R G GoldieJ L Wale

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