PMID: 8959748Jan 1, 1996Paper

Relaxation of human temporal artery by endothelin ETB receptors

Peptides
G A LucasL Edvinsson

Abstract

Endothelin receptors have been characterized in human temporal artery by molecular biological methods and in vitro pharmacology. Reverse transcriptase-polymerase chain reaction was used to detect mRNA encoding ETA and ETB receptors in normal and endothelium-denuded arteries. Vasomotor response experiments with a specific ETA antagonist (FR 139317) suggested the presence of ETA subtypes. Marked ETB-mediated relaxation was obtained with ET-3 when ETA activity was blocked in precontracted arteries. Relaxation was significantly reduced by bosentan, indomethacin, and a nitric oxide synthase inhibitor. It may be speculated that the relaxant activity is mediated through ETB1 receptors.

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Citations

Sep 30, 2000·European Journal of Pharmacology·L R WhiteJ Aasly
Oct 20, 1998·Acta Physiologica Scandinavica·L R WhiteL Edvinsson
Mar 10, 2016·Pharmacological Reviews·Anthony P DavenportJanet J Maguire
Aug 19, 2014·British Journal of Pharmacology·J J Maguire, A P Davenport

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