Relaxation of insulin-like growth factor 2 gene imprinting in esophageal cancer

International Journal of Cancer. Journal International Du Cancer
M MoriT Akiyoshi

Abstract

Paternal allele-specific expression is identified for the insulin-like growth factor 2 (IGF2) gene. Relaxation or loss of IGF2 imprinting, however, has been reported in several neoplasms. We studied the expression of IGF2 mRNA in 35 squamous cancers of the esophagus and searched for the presence or absence of relaxation of IGF2 imprinting. In 28 (80%) cases, IGF2 mRNA was overexpressed in the tumor tissues (T) compared to the normal tissues (N). The patients whose tumor invaded the adventitia showed a higher T/N ratio than those whose tumor was restricted to the musculi propria layer. Heterozygosity was determined by using the Apa I polymorphism in exon 9. Thirteen of 35 cases showed heterozygosity. In these 13 cases, a similar analysis was performed on cDNA obtained by reverse transcriptase-polymerase chain reaction. Consequently, 7 cases disclosed relaxation of IGF2 imprinting in the tumor tissue. The cases of esophageal cancer with relaxation of IGF2 imprinting showed a higher T/N ratio and deeper invasion than those without relaxation. The results suggest that overexpression of IGF2 mRNA plays an important role in esophageal cancer and, in certain cases, is associated with relaxation of IGF2 imprinting.

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Citations

Jun 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Chang-Qi ZhuMing-Sound Tsao
Dec 15, 2010·World Journal of Gastroenterology : WJG·Yasushi AdachiYasuhisa Shinomura
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T AiharaS Imaoka
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K ShimodaG F Barnard
Nov 22, 2005·Journal of Surgical Oncology·David S Schrump, Dao M Nguyen
Sep 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yasushi AdachiYasuhisa Shinomura
Jun 10, 2017·World Journal of Gastroenterology : WJG·Yasushi AdachiAkiko Tamakoshi
Dec 13, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Linda A FeaginsRhonda F Souza
Jan 20, 1999·Molecular Pathology : MP·J A Joyce, P N Schofield
Aug 15, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·T GaoS Wang
Feb 1, 2000·Trends in Biotechnology·J A Thomson, J S Odorico

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