Relaxation of isolated dog coronary artery induced by propranolol

European Journal of Pharmacology
M Sakanashi, K Nishi

Abstract

The effects of propranolol and atenolol on isolated dog coronary arteries contracted with potassium were investigated in vitro. Propranolol at high concentrations (3 x 10(-5)-10(-4) M) produced relaxations of the coronary arterial strips, which were restored or prevented by exogenous calcium ions. Atenolol (10(-5)-10(-4) M) never changed the tension of the strips. The results suggest that propranolol may inhibit the coronary arteries through its calcium antagonistic action.

References

Dec 1, 1987·European Journal of Pharmacology·K NoguchiM Sakanashi
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·S ShibataN Satake
Aug 1, 1987·Journal of the American College of Cardiology·A GaglioneH P Krayenbuehl
May 1, 1984·Stroke; a Journal of Cerebral Circulation·J A CapraroJ R Little
Feb 1, 1982·Circulation·R M RobertsonD Robertson

Citations

Aug 1, 1976·The Journal of Allergy and Clinical Immunology·H M Guirgis, R G Townley
Jun 13, 1980·European Journal of Pharmacology·M Sakanashi, K I Yonemura
May 1, 1965·Circulation Research·R C ZUBERBUHLER, D F BOHR

Related Concepts

Muscle, Smooth, Vascular
Calcium [EPC]
Calcium
Potassium
Calcium ion
Contraction (Finding)
Muscle Relaxation Phase
Entire Coronary Artery
Sinus Node Artery
Coronary Artery

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