Relaxation of surface-tethered polymers under moderate confinement

Soft Matter
Johannes HartmannSteffen Hardt

Abstract

We study the relaxation of surface-tethered polymers in microchannels under moderate confinement (i.e. h ∼ Rg, where h is the channel height and Rg is the radius of gyration of the polymer) by experiments with fluorescence-marked DNA molecules and coupled lattice-Boltzmann/molecular dynamics simulations. The determined scaling exponent suggests that the relaxation is dominated by Zimm-dynamics with significant intra-chain hydrodynamic interactions. The relaxation of the DNA molecules is slower in shallower channels, indicating a pronounced effect of confinement on the longest relaxation time. An experimental correlation is obtained for the longest relaxation time as a function of the molecular contour length and the channel height. Good agreement between the experimental and the simulation results is found.

References

Apr 7, 1995·Science·T T PerkinsS Chu
Jun 27, 1997·Science·T T PerkinsS Chu
Dec 19, 2002·Biophysical Chemistry·Dirk Stigter
Jul 9, 2004·Biophysical Journal·Sean Ferree, Harvey W Blanch
Jul 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonas O TegenfeldtRobert H Austin
Feb 9, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Y-L ChenP S Doyle
Apr 15, 2005·Mutation Research·Eugene Y Chan
Jun 5, 2007·Nature Protocols·Cesar MateoJose M Guisan
Feb 22, 1991·Science·S T Milner
Nov 6, 2007·The Journal of Chemical Physics·Axel ArnoldSuckjoon Jun
Feb 1, 2008·Physical Review Letters·A BalducciP S Doyle
Jul 23, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Theo Odijk
Aug 8, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Youngkyun JungBae-Yeun Ha
Sep 7, 2006·Physical Chemistry Chemical Physics : PCCP·Feng Zhou, Wilhelm T S Huck
Sep 28, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hitoshi UemuraYasuyuki Kimura
Nov 9, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·P-K LinY-L Chen
Dec 7, 2013·Biomicrofluidics·Douglas R TreeKevin D Dorfman
Nov 5, 2014·Soft Matter·Binu KundukadPatrick S Doyle
Dec 8, 2015·Analytical Chemistry·Rachel K HarstadMichael T Bowser
Jul 25, 2017·The Journal of Chemical Physics·Kai SzuttorJens Smiatek

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BETA
fluorescence microscopy

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