PMID: 7536713Apr 1, 1995Paper

Relaxation of the aorta during hypoxia is impaired in chronically hypertensive rats

Hypertension
H TaguchiD D Heistad

Abstract

We investigated mechanisms by which hypoxia produces relaxation of the aorta and tested the hypothesis that these mechanisms are altered during chronic hypertension. Tension of thoracic aortae from normotensive Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) was measured in an organ bath under control conditions and at two levels of hypoxia. In WKY rats, mild and severe hypoxia produced relaxation of the aortae (precontracted with phenylephrine) by 33 +/- 4% and 82 +/- 3%, respectively (mean +/- SEM). Removal of endothelium or administration of NG-nitro-L-arginine (10(-4) mol/L), an inhibitor of nitric oxide synthase, abolished relaxation of the aortae in response to mild hypoxia but did not affect relaxation during severe hypoxia. Glibenclamide (10(-6) mol/L), an inhibitor of potassium channels, attenuated relaxation of the aortae during mild and severe hypoxia by 49 +/- 16% and 74 +/- 4%, respectively. In SHRSP, mild hypoxia produced little relaxation of the aortae (3 +/- 4%, P < .05 compared with WKY). Indomethacin did not increase relaxation to mild hypoxia in SHRSP, which suggests that a cyclooxygenase-derived contracting factor does not contribute to impaired relaxation. Severe hypoxia rel...Continue Reading

References

Jul 1, 1992·Trends in Pharmacological Sciences·D Escande, I Cavero
Nov 11, 1991·The Journal of Clinical Investigation·J P CookeV J Dzau
Nov 1, 1989·Trends in Pharmacological Sciences·U Quast, N S Cook
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Jan 1, 1993·Annual Review of Pharmacology and Toxicology·G Edwards, A H Weston
May 1, 1993·The American Journal of Physiology·G H Gelband, J R McCullough

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Citations

Oct 13, 2005·Journal of Cardiovascular Pharmacology·Jonathan E GravesNeil W Kooy
May 1, 1996·Alcoholism, Clinical and Experimental Research·W G Mayhan, S P Didion
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jon J AndresenDonald D Heistad

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