Relaxed natural selection contributes to global obesity increase more in males than in females due to more environmental modifications in female body mass

PloS One
Wenpeng You, Maciej Henneberg

Abstract

Relaxed natural selection, measured by Biological State Index (Ibs), results in unfavourable genes/mutations accumulation in population. Obesity is partly heritable. We aim to examine and compare the effects of relaxed natural selection on male and female obesity prevalence. Data for 191 countries of the world were captured for this ecological study. Curvilinear regressions, bivariate and partial correlations, linear mixed models and multivariate linear regression analyses were used to examine the relationship between Ibs and sex-specific obesity prevalence. Per capita GDP, urbanization and caloric intake were controlled for as the confounding factors. Fisher r-to-z transformation, R2 increment in multivariate regression and F-test were used to compare the correlations. Curvilinear regressions, bivariate and partial correlations (controlled for GDP, urbanization and calories) revealed that Ibs was significantly correlated to obesity prevalence of both sexes, but significantly stronger to male than to female obesity prevalence. Curvilinear regression models also showed strong correlations. Mixed linear models, with effects of GDP, urbanisation and caloric intake controlled for, showed that male and female average obesity prevale...Continue Reading

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Citations

Sep 29, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Songjia LaiShiyi Chen
Mar 14, 2021·Explore : the Journal of Science and Healing·Helané WahbehMarcela V Karpuj

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