Relaxivities of paramagnetic liposomes: on the importance of the chain type and the length of the amphiphilic complex.

European Biophysics Journal : EBJ
Sophie LaurentRobert N Muller

Abstract

Nuclear magnetic relaxation dispersion (NMRD) profiles of unilamellar DPPC liposomes incorporating Gd-DTPA-bisamides with alkyl chains of 12 to 18 C atoms in their external and internal layers were recorded in order to study the influence that the chain length and structure of Gd-bisamides incorporated in the liposomal membrane have on their proton relaxivity. The NMRD profiles recorded at 310 K show that the relaxivity reaches a minimum value when the carbon chain lengths of the phospholipid and of the Gd complex match and is at a maximum in the presence of a carbon-carbon double bond. For these DPPC paramagnetic liposomes, the longer the aliphatic chains of the complex, the larger will be its immobilization in the membrane. In addition, the presence of an unsaturated carbon-carbon bond in the alkyl chain of the Gd complex induces an increase of its mobility and of its water exchange rate with, as a result, a much greater efficiency as an MRI contrast agent.

References

Sep 1, 1993·Chemistry and Physics of Lipids·M Winterhalter, D D Lasic
Jun 1, 1996·Molecular Medicine Today·V P Torchilin
Feb 18, 2003·The Journal of Allergy and Clinical Immunology·Kameswari S KonduriPattisapu R J Gangadharam
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Pia Freyschmidt-PaulRolf Hoffmann
Mar 23, 2004·Current Pharmaceutical Design·Yoko Shoji, Hideki Nakashima
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Knut-Egil LøklingSigrid L Fossheim
May 6, 2004·Cancer Research·Noemi KedeiPeter M Blumberg
Jul 13, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Knut-Egil LøklingRoald Skurtveit
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ivano BertiniClaudio Luchinat
Sep 13, 2005·Magma·G J StrijkersK Nicolay
Dec 29, 2006·Contrast Media & Molecular Imaging·Alessandro BargeFranco Fedeli
Mar 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Sophie LaurentRobert N Muller

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Citations

May 19, 2010·International Journal of Molecular Sciences·Nazila Kamaly, Andrew D Miller
Aug 24, 2011·Contrast Media & Molecular Imaging·Sophie LaurentRobert N Muller
May 25, 2013·NMR in Biomedicine·Sander LangereisKlaas Nicolay
Aug 30, 2011·Analytical Biochemistry·Michael D LeipoldMark Nitz
Sep 9, 2015·Bioinorganic Chemistry and Applications·Simone Rodrigues SilvaCynthia Demicheli
Dec 25, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Jesús AgullaPedro Ramos-Cabrer
Apr 24, 2012·Biomaterials·Yongjun Liu, Na Zhang
Jul 21, 2010·Biophysical Journal·Gelen RodríguezOlga López
Sep 19, 2016·Advanced Drug Delivery Reviews·Prabhani U AtukoraleEfstathios Karathanasis
Nov 28, 2015·Scientific Reports·Maayke M P KuijtenBakhos A Tannous
Feb 2, 2019·Drug Metabolism and Personalized Therapy·Mehran Alavi, Mehrdad Hamidi

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