PMID: 9442375Jan 27, 1998Paper

RelB is a key player for both kappa B-dependent transcription and demethylation in B cells

Immunobiology
B KistlerT Wirth

Abstract

NF-kappa B was originally identified as a B cell-specific nuclear factor binding to the intronic kappa-light-chain enhancer element. It is found constitutively in the nucleus of mature B and plasma cells. In other cell types including pre-B cells, NF-kappa B is sequestered in the cytoplasm but can be induced by a variety of stimuli. In contrast to essentially all other mature B cells and plasma cell lines, the S107 plasmacytoma cell line lacks both constitutive and inducible kappa B-binding activity. A molecular characterization of the defect in these S107 cells suggests that the primary defect lies in the signal transduction pathway leading to NF-kappa B induction. Ectopic expression of RelB after stable transfection of these cells restores constitutive nuclear kappa B-binding activity. Moreover, kappa B-dependent transcription is also restored. Finally we demonstrate, that in contrast to parental S107 cells, the stable RelB transfectants have also regained the ability to specifically demethylate a transfected immunoglobulin kappa-locus. These data suggest that RelB is critically involved in both B cell-specific transcription and demethylation directed by the intronic kappa-enhancer element.

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Jan 1, 1992·Free Radical Research Communications·R SchreckP A Baeuerle
Dec 1, 1988·Baillière's Clinical Rheumatology·J P Pandey
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W PierceD Baltimore
Oct 28, 1988·Science·P A Baeuerle, D Baltimore
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·Y BergmanD Baltimore
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
May 7, 1998·The International Journal of Biochemistry & Cell Biology·C XiaP Woo

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Citations

Dec 26, 2001·European Journal of Immunology·Sandrine GuerinPhilippe Naquet
Jan 28, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Moshe Szyf
Oct 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Matthew Inlay, Yang Xu
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·B J O'SullivanR Thomas
Mar 14, 2009·Differentiation; Research in Biological Diversity·Christof Niehrs
Jun 14, 2005·Biochemistry. Biokhimii︠a︡·M Szyf
Apr 5, 2018·Epigenomics·Lisa BoureauMoshe Szyf

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