RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.

Annals of the New York Academy of Sciences
Aaron K HolleyWilliam H St Clair

Abstract

Radiation therapy is in the front line for treatment of localized prostate cancer. However, a significant percentage of patients have radiation-resistant disease. The NF-kappaB pathway is an important factor for radiation resistance, and the classical (canonical) pathway is thought to confer protection of prostate cancer cells from ionizing radiation. Recently, the alternative (non-canonical) pathway, which is involved in prostate cancer aggressiveness, has also been shown to be important for radiation resistance in prostate cancer. The alternative NF-kappaB pathway component RelB protects prostate cancer cells from the detrimental effects of ionizing radiation, in part, by stimulating expression of the mitochondria-localized antioxidant enzyme manganese superoxide dismutase (MnSOD). Blocking RelB activation suppresses MnSOD expression and sensitizes prostate cancer cells to radiation. These results suggest that RelB-mediated modulation of the antioxidant capacity of prostate cancer cells is an important mechanism of radiation resistance. Therefore, targeting RelB activation may prove to be a valuable weapon in the oncologist's arsenal to defeat aggressive and radiation-resistant prostate cancer.

References

Sep 8, 1978·Science·I Fridovich
Aug 1, 1991·The Journal of Clinical Investigation·M A BrachD Kufe
Oct 1, 1993·Molecular and Cellular Biology·C Kunsch, C A Rosen
Oct 6, 1997·The Journal of Biological Chemistry·D ChilovK Alitalo
Apr 29, 1998·Free Radical Biology & Medicine·J SunZ Ge
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Jul 20, 1999·Molecular and Cellular Biology·D C GuttridgeA S Baldwin
Mar 25, 2000·Molecular and Cellular Biology·C ChenC Gélinas
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Feb 22, 2001·The Journal of Experimental Medicine·T KaishoS Akira
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E AlcamoD Baltimore
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Feb 28, 2002·Molecular Cell·Guoqing ChenDavid V Goeddel
Jul 12, 2002·The Prostate·Junghan SuhArnold B Rabson
Mar 18, 2003·Molecular and Cellular Biology·Guozheng GuoJian Jian Li
Apr 17, 2004·The Journal of Biological Chemistry·Sanjit K DharDaret K St Clair
May 12, 2004·Current Medicinal Chemistry·G PoliE Chiarpotto
May 18, 2004·Trends in Immunology·Giuseppina Bonizzi, Michael Karin
Jul 9, 2004·American Journal of Physiology. Cell Physiology·Henry Jay FormanMartine Torres
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Damian CarragherJorge Caamaño
Feb 12, 2005·Antioxidants & Redox Signaling·Yasuaki KabeHiroshi Handa
May 19, 2005·International Journal of Cancer. Journal International Du Cancer·Emina TorlakovicSophie D Fosså
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dan KinoshitaMitsuru Matsumoto
May 13, 2006·Journal of Carcinogenesis·Gulam Waris, Haseeb Ahsan
Aug 17, 2006·Antioxidants & Redox Signaling·David Gius, Douglas R Spitz

❮ Previous
Next ❯

Citations

Sep 18, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jingjing XuFeng Guo
Jul 31, 2012·Journal of Radiation Research·Konstantina FloratouPanagiota Matsouka
Oct 8, 2013·Antioxidants & Redox Signaling·Aaron K HolleyWilliam H St Clair
Apr 16, 2013·Antioxidants & Redox Signaling·Demet Candas, Jian Jian Li
Aug 8, 2013·Antioxidants & Redox Signaling·Mitchell C ColemanDouglas R Spitz
Jan 1, 2013·Breast Cancer Management·Cheikh Menaa, Jian Jian Li
Nov 17, 2015·International Journal of Molecular Sciences·Byeong Mo KimYonggeun Hong
Oct 1, 2015·The Journal of Nutritional Biochemistry·Marit KolbergIngvild Paur
Apr 6, 2016·Frontiers in Oncology·Christine E HellwegChrista Baumstark-Khan
Mar 15, 2013·International Journal of Radiation Biology·Katia StankovaRayna Boteva
May 10, 2012·Gene·Ahmet KorkmazRussel J Reiter
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Katia StankovaRayna Boteva
Nov 23, 2017·Antioxidants & Redox Signaling·Leyla FouaniDes R Richardson
Aug 1, 2018·International Journal of Molecular Sciences·Christine E HellwegChrista Baumstark-Khan
Mar 28, 2013·Extremophiles : Life Under Extreme Conditions·Kimberly M WebbJocelyne DiRuggiero
Nov 27, 2018·Cancer Cell International·Xiaojun ZhouFeng Guo
Sep 11, 2020·Oxidative Medicine and Cellular Longevity·Hong FengHai-Han Liao
Jul 13, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Stefka Mincheva-Tasheva, Rosa M Soler
Jun 8, 2017·Frontiers in Oncology·Osama Muhammad MariaThierry Muanza
Jul 29, 2018·Journal of Experimental & Clinical Cancer Research : CR·Yanyan ZhangYong Xu
Mar 14, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Stephen T Sonis
Nov 5, 2019·Biochemical and Biophysical Research Communications·Soichiro ShigaYoshio Hosoi
Jun 19, 2021·Frontiers in Oncology·Chiara GaleazAlessandra Bisio
Mar 20, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Meera PatelJoanne Edwards

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.