PMID: 8960398Sep 1, 1996Paper

Release and actions of inhibitory prostaglandins from canine tracheal epithelium

Canadian Journal of Physiology and Pharmacology
I McGrogan, E E Daniel

Abstract

This study evaluated the sources and actions of inhibitory prostanoids on canine tracheal smooth muscle to determine if these accounted for epithelium derived relaxing factor activity. Concentration-response curves of canine tracheal smooth muscle were generated to carbachol in the presence and absence of the epithelium and (or) indomethacin, a cyclooxygenase inhibitor. Removal of the epithelium or addition of indomethacin (10(-5) M) in the presence of the epithelium shifted the curve significantly leftward compared with epithelial-intact tissue. Furthermore, addition of indomethacin to epithelial-denuded tissue produced the greatest shift in the curve. Removal of the epithelium increased contractility in response to electrical-field stimulation at intermediate frequencies compared with epithelium-intact tissues. The addition of indomethacin to epithelium-intact tissue also increased the contractile responses. Removal of the epithelium in the presence of indomethacin further increased responses. Radioimmunoassay of muscle bath fluid indicated that the inhibitory prostanoids prostaglandin I2 (PGI2) and prostaglandin E2 (PGE2) were released. PGI2 was released from the epithelium as well as from a nonepithelial source. PGE2 was re...Continue Reading

Citations

Jan 5, 2002·Clinical and Diagnostic Laboratory Immunology·Jörg EberhardYahya Açil
Aug 15, 2000·European Journal of Pharmacology·B E McParlandJ L Black
Mar 11, 2008·Pulmonary Pharmacology & Therapeutics·Richard W Chapman
May 18, 2004·European Journal of Pharmacology·Katsuo KoikeYoshio Tanaka

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