Release from polymeric prodrugs: linkages and their degradation

Journal of Pharmaceutical Sciences
Ajit Joseph M D'Souza, Elizabeth M Topp

Abstract

Polymeric prodrugs have evolved into a very useful class of drug delivery agents. Numerous polymeric prodrugs have been prepared for applications ranging from passive drug targeting to controlled release. The mechanistic aspects of the release processes, however, have not been clearly delineated. This review highlights the salient features of the chemical reactions that are responsible for drug release from these systems. The mechanisms of release from polymeric prodrugs employing various chemical linkages, esters, carbonates, carbamates, C=N linkage and amides, are discussed.

References

Sep 1, 1992·Journal of Pharmaceutical Sciences·R Mehvar, T L Shepard
Sep 22, 1992·Biochemistry·H Grøn, K Breddam
Apr 20, 1967·Biochemical and Biophysical Research Communications·I Schechter, A Berger
May 14, 1980·Biochemical and Biophysical Research Communications·R DuncanJ Kopecek
Jul 1, 1997·Journal of Pharmaceutical Sciences·D ShanB Wang
Jul 1, 1997·Protein Science : a Publication of the Protein Society·P MajerJ W Erickson
May 23, 1998·Annual Review of Pharmacology and Toxicology·T Satoh, M Hosokawa
Jan 23, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·P J JulyanD J Kerr
Feb 11, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·H SoyezE Schacht
Oct 8, 1999·Il Farmaco·F M Veronese, M Morpurgo
Mar 8, 2000·Critical Reviews in Therapeutic Drug Carrier Systems·F KratzM T Schütte
Mar 10, 2000·Biochimica Et Biophysica Acta·J MaiB F Sloane
Jul 7, 1997·Advanced Drug Delivery Reviews·R K Jain
Aug 19, 2000·Cellular and Molecular Life Sciences : CMLS·P A AndreasenH H Petersen
Jan 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zheng-Rong LuJindrich Kopecek
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yun H ChoeRichard B Greenwald
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang YooTae Gwan Park
Aug 28, 2002·The Journal of Pharmacy and Pharmacology·L F WangW B Chen
Sep 3, 2002·Advanced Drug Delivery Reviews·Ashutosh ChilkotiDrazen Raucher
Sep 3, 2002·Advanced Drug Delivery Reviews·Chun Li
Feb 5, 2003·Advanced Drug Delivery Reviews·Richard B GreenwaldCharles D Conover
Mar 4, 2003·Nature Reviews. Drug Discovery·J Milton Harris, Robert B Chess
Mar 20, 2003·Bioconjugate Chemistry·Niren MurthyPatrick S Stayton
May 14, 2003·Biomacromolecules·Barbara G StubbeJo Demeester
May 17, 2003·Nature Reviews. Drug Discovery·Ruth Duncan
May 22, 2003·Bioconjugate Chemistry·Charles D ConoverRichard B Greenwald
Jul 29, 2003·Bioorganic & Medicinal Chemistry Letters·Paula RodriguesFelix Kratz
Dec 20, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ajit Joseph M D'SouzaElizabeth M Topp

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Citations

Dec 25, 2010·Pharmaceutical Research·Wassana WijagkanalanMitsuru Hashida
May 1, 2009·Bioconjugate Chemistry·Omathanu PerumalRangaramanujam M Kannan
Dec 25, 2012·Molecular Pharmaceutics·Nathalie M PinkertonRobert K Prud'homme
Jul 26, 2005·Chemical Communications : Chem Comm·Paul A BertinSonBinh T Nguyen
Jul 9, 2009·Chemical Communications : Chem Comm·Byeong-Su KimPaula T Hammond
Jul 24, 2013·Preparative Biochemistry & Biotechnology·Zahoor Qadir SamraMubashar Mustaneer Ahmad
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Betiana FeliceSeeram Ramakrishna
Apr 11, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Piyanuch WongananZhengrong Cui
Sep 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jun YangPhilip S Low
Jan 26, 2016·Trends in Biotechnology·Alessandro PellisLucia Gardossi
Apr 24, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Danbo YangLei Yu
Oct 22, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tessa LuhmannLorenz Meinel
May 14, 2011·Advanced Drug Delivery Reviews·Suzanne M D'Addio, Robert K Prud'homme
Jun 23, 2009·International Journal of Pharmaceutics·Yong-Jiang ZhaoGuang-Hui Ma
Feb 6, 2009·Biotechnology Progress·Maggie LawP Chen
Mar 2, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sarvesh K AgrawalSurita R Bhatia
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Matthew D BurkeSaad A Khan
Sep 23, 2010·Pharmaceutical Development and Technology·Bridg'ette IsraelAnthony C Capomacchia
Nov 9, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Saurabh Wadhwa, Russell J Mumper
Jul 30, 2015·Biomaterials Science·N D StebbinsK E Uhrich
Jun 9, 2005·Journal of Biomedical Materials Research. Part a·John W DuBoseAndrew T Metters
Mar 28, 2008·Bioorganicheskaia khimiia·I Iu Ponedel'kinaV N Odinokov
Feb 6, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Semonti NandiJayant J Khandare
Aug 23, 2018·Drug Delivery and Translational Research·Jasmin MonparaPradeep Vavia
Jun 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Taejun EomAnzar Khan

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