PMID: 8939408Dec 1, 1996Paper

Release kinetics of serum cardiac troponin I in ischemic myocardial injury

Clinical Biochemistry
J P BertinchantB Pau

Abstract

The study was undertaken to evaluate the release kinetics of cardiac troponin I (cTn-I) in ischemic myocardial injury. The reference range for cTn-I was established by determination of cTn-I in sera and plasma obtained from 622 healthy volunteers (Group 1). cTn-I was compared to: (a) Creatine kinase (CK) MB mass and myoglobin in 12 patients with severe skeletal muscle damage (Group 2); (b) CK-MB activity in 48 patients with myocardial infarction (MI) receiving intravenous thrombolysis (Group 3) (in this group, an additional 43 patients with MI were analyzed separately to characterize cTn-I patterns in thrombolyzed and nonthrombolyzed populations): and in 44 patients with unstable angina (Group 4). In Groups 1 and 2, no positive results (> or = 0.1 microgram/L) were obtained. In Group 3, the time-courses of cTn-I were mostly monophasic in form. A pathologic increase occurred earlier in cTn-I than in CK-MB activity (p = 0.0002); the period with increased cTn-I was longer (p = 0.001), the overall sensitivity of cTn-I (93.9%) was higher than that of CK-MB activity (p = 0.00001). cTn-I was more sensitive at admission (p = 0.0004). In additional patients, the cTn-I peak occurred and cTn-I disappeared significantly later in nonthrombo...Continue Reading

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Citations

Jul 15, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·J P BertinchantM Dauzat
May 2, 2002·Clinical Biochemistry·Isabelle GiulianiCatherine Larue
May 22, 2008·Analytical Chemistry·Ewa HeydukTomasz Heyduk
Jul 1, 2009·Analytical Chemistry·Ling Tian, Tomasz Heyduk
Jul 17, 2012·Pediatric Research·Daniel C VijlbriefWillem B de Vries
Jul 4, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·A LimkakengJ E Hollander
May 1, 2004·BMJ : British Medical Journal·Peter AmmannHans Rickli
Oct 26, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Pelin KaracaSertac Cicek
Nov 22, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·K PenttiläG Svanas
Aug 26, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·C LarueC Granier
Aug 9, 2011·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Joann SlackVirginia Reef
Apr 6, 2001·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·G N OnuohaB Pau
Jul 20, 2007·American Journal of Clinical Pathology·Stacy E F MelansonPetr Jarolim
Oct 14, 2008·European Journal of Internal Medicine·Natale Daniele BrunettiMatteo Di Biase
Mar 10, 2007·International Journal of Cardiology·Tsuyoshi IsonoToshiji Iwasaka
Mar 11, 2015·Journal of Veterinary Emergency and Critical Care·Cristobal Navas de SolisJoAnn Slack
Jan 16, 2015·Journal of Cardiovascular Electrophysiology·Gareth J WynnDhiraj Gupta
Jul 20, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hitoshi NaraokaHideaki Tojo
Apr 27, 2000·The American Journal of Cardiology·S FuchsM B Leon
Nov 9, 2002·The American Journal of Cardiology·Prince J KannankerilDavid F Wax
Jul 23, 2015·Journal of Ginseng Research·Adithan AravinthanJong-Hoon Kim
Nov 5, 2005·Forensic Science International : Synergy·Jan PeterJan Dressler

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