PMID: 11920769Mar 29, 2002Paper

Release mechanisms from gentamicin loaded poly(lactic-co-glycolic acid) (PLGA) microparticles

Journal of Pharmaceutical Sciences
Wolfgang Friess, Monika Schlapp

Abstract

To provide local gentamicin delivery for 1 week based on a biodegradable system, poly(lactic-co-glycolic acid) (PLGA) microparticles were developed utilizing a 50/50 blend of Resomer RG 502H, an uncapped variety of 13.5 kD, and Resomer RG 503, an endcapped polymer of 36.2 kD. The liberation mechanism was investigated by analysis of morphological changes and thermal analysis focusing on the polymer glass transition temperature (T(g)) and the mechanical properties. The release of gentamicin was related to a structural breakdown of the particles reaching a critical molecular weight. A T(g) of < 37 degrees C in the hydrated state was not indicative of collapse and agglomeration of the particles because the mechanical strength of the polymer structures in the rubbery state may still render sufficient support. As the gap between incubation temperature and T(g) widened, the mechanical stability of the PLGA microparticles decreased and became decisive. Particles prepared with RG 502H show a lower ability to bear mechanical stress than RG 503 and 50/50 RG 502H/RG 503 microparticles.

References

May 20, 1999·International Journal of Pharmaceutics·Y Y HuangT W Tzeng
Feb 17, 2000·International Journal of Pharmaceutics·E LeoM T Bernabei
Jun 6, 2000·Advanced Drug Delivery Reviews·J W McGinity, P B O'Donnell
Jun 8, 2000·Annals of the New York Academy of Sciences·J M AranD Dulon
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H B RavivarapuP P DeLuca

❮ Previous
Next ❯

Citations

Dec 2, 2005·Pharmaceutical Research·Sridhar DuvvuriAshim K Mitra
Nov 19, 2003·Advanced Drug Delivery Reviews·Zbigniew Ruszczak, Wolfgang Friess
Jul 9, 2005·Journal of Biomaterials Science. Polymer Edition·A SantoveñaJ B Fariña
Apr 26, 2013·Critical Reviews in Therapeutic Drug Carrier Systems·Daniel J Hines, David L Kaplan
Dec 13, 2012·The Journal of the Acoustical Society of America·François CoulouvratWladimir Urbach
Sep 23, 2014·Journal of Pharmaceutical Sciences·Milan Dittrich, Eva Snejdrova
Jun 7, 2011·International Journal of Pharmaceutics·Susanne FredenbergAnders Axelsson
Dec 30, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ming WuClive J Roberts
Mar 12, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bing GuDiane J Burgess
Feb 25, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wolfgang Friess, Monika Schlapp
Dec 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·H-I ChangA G A Coombes
Aug 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Paolo BlasiPatrick P DeLuca
Jan 22, 2014·Journal of Biomedical Materials Research. Part a·Hernando PachecoAhmed El-Ghannam
Aug 11, 2016·Journal of Biomedical Materials Research. Part a·Zhaowei ChuYubo Fan
Sep 13, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haiyan Li, Jiang Chang
Apr 29, 2016·Journal of Biomedical Materials Research. Part a·Zhaowei ChuYubo Fan
Jul 4, 2007·Journal of Biomedical Materials Research. Part a·H-I ChangA G A Coombes
Mar 1, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Pavan Kumar NaraharisettiChi-Hwa Wang
Aug 30, 2008·Journal of Microencapsulation·Enxian LuCarmen Popescu
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Fatemeh Sadat Tabatabaei MirakabadSang Woo Joo
Sep 18, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ofra BennyRona S Carroll
Dec 29, 2007·Pharmaceutical Development and Technology·Susanne FredenbergAnders Axelsson
Sep 9, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xia LiJianlin Shi
Jun 18, 2002·Pharmaceutical Development and Technology·Wolfgang Friess, Monika Schlapp
Feb 8, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jiaen WuGuangcui Yuan
Dec 6, 2020·Biointerphases·Hamish PoliLisbeth Grøndahl
Jun 15, 2004·Analytical Chemistry·Sergey Vyazovkin
Jun 1, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·C BodeJ Siepmann
Jul 28, 2019·International Journal of Pharmaceutics·C BodeJ Siepmann
Nov 15, 2019·International Journal of Pharmaceutics·F TamaniJ Siepmann
Sep 27, 2012·Molecular Pharmaceutics·Sam N RothsteinSteven R Little
Apr 19, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Colm McManamonMichael A Morris
Sep 29, 2020·Nano Letters·Nourin AlsharifKeith A Brown

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.