PMID: 43365Dec 1, 1979

Release of [3H]noradrenaline induced by 5-hydroxytryptamine from cat pial arteries

The Journal of Pharmacy and Pharmacology
J MarinC F Sánchez


Pial arteries of cats were used to analyse the effects of 5-hydroxytryptamine (5-HT) on the release of [3H]noradrenaline. To achieve this the vessels were preincubated with [3H]noradrenaline and the effect of different concentrations of 5-HT (10(-6), 10(-5), 10(-4) M) on the release of tritium was studied. 5-HT elicited release of radioactivity in a dose-dependent manner. Removal of both superior cervical sympathetic ganglia 15 days before the experiment of pretreatment of the animals with reserpine (3 mg kg-1, total dose) produced a significant decrease in the outflow of tritium induced by 5-HT. In these arteries, the amount of radioactivity retained at the end of the experiment was much diminished. Cocaine (10(-6) M) caused a significant decrease in the tritium efflux induced by 5-HT (1"0(-5) M). These results show that 5-HT has an indirect adrenergic effect in the pial arteries of the cat only at high doses of 5-HT, and confirm that sympathetic innervation of these vessels mainly comes from the superior cervical ganglia.


Dec 1, 1979·The Journal of Pharmacy and Pharmacology·J MarinC F Sánchez
Jul 1, 1976·Circulation Research·T J LeeJ A Bevan
Oct 1, 1971·Acta Physiologica Scandinavica·G FillionB Uvnäs
Nov 1, 1973·Acta Physiologica Scandinavica·O A Nedergaard, J Schrold
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Iwayama


Jan 1, 1986·Neuroscience and Biobehavioral Reviews·G C Palmer
Jan 1, 1982·General Pharmacology·J Marin, F Rivilla
Jan 1, 1990·General Pharmacology·M T BarrúsJ Marin
Aug 1, 1985·The Journal of Dairy Research·G Vandeputte-Van MessonG Peeters
Dec 1, 1979·The Journal of Pharmacy and Pharmacology·J MarinC F Sánchez
Sep 1, 1980·The Journal of Pharmacy and Pharmacology·J Marin, C F Sánchez

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